Innovative dissolving microneedles for enhanced delivery of alpha arbutin and ascorbic acid: a novel LC–MS quantification approach

IF 4.7 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Advances Pub Date : 2024-12-16 DOI:10.1039/D4MA00908H

Ola Tarawneh, Sara Almasri, Ala A. Alhusban, Mohammad Hailat, Lama Hamadneh, Juhaina M. Abu Ershaid, Zeyad Hailat and Yahia F. Makableh

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Abstract

This study presents a novel dissolving microneedles (MN) formulation designed to deliver alpha arbutin (AA) and ascorbic acid for hyperpigmentation treatment. Utilizing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP-K90), we successfully prepared and characterized MN arrays with high drug loading efficiencies of 89.01% for AA and 94.09% for ascorbic acid. A pioneering liquid chromatography–tandem mass spectrometry (LC–MS) technique was developed for simultaneous drug quantification, achieving precision and accuracy as per FDA guidelines. Our MN demonstrated excellent mechanical properties, with effective skin penetration and dissolution within 5 minutes and permeation rates of 4.28% h⁻¹ for AA and 3.61% h⁻¹ for ascorbic acid. This innovative approach offers a promising platform for the transdermal delivery of active compounds, highlighting significant advancements in drug delivery technology.

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创新的溶解微针用于增强α熊果苷和抗坏血酸的递送：一种新的LC-MS定量方法

本研究提出了一种新的可溶性微针（MN）制剂，设计用于递送α熊果苷（AA）和抗坏血酸治疗色素沉着。以羟丙基甲基纤维素（HPMC）和聚乙烯吡咯烷酮（PVP-K90）为原料，制备了载药效率为89.01%的AA和94.09%的抗坏血酸MN阵列。开发了一种开创性的液相色谱-串联质谱（LC-MS）技术，用于同时进行药物定量，达到了FDA指南的精确性和准确性。我们的MN具有优异的机械性能，在5分钟内具有有效的皮肤渗透和溶解，AA和抗坏血酸的渗透率分别为4.28%和3.61% h−1。这种创新的方法为活性化合物的经皮给药提供了一个有前途的平台，突出了药物给药技术的重大进步。

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