Synthesis of dual-responsive carboxymethyl cellulose–based nanogels for drug delivery applications

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL Colloid and Polymer Science Pub Date : 2024-11-09 DOI:10.1007/s00396-024-05350-y

Yuanpeng Cai, Danyang Li, Shaohua Peng, Hui Liu

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Abstract

Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate (MEO₃MA), methacrylic acid (MAA), and natural biopolymer carboxymethyl cellulose (CMC) were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques, and the responsive behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38 °C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. With doxorubicin (DOX) as a model drug, the nanogels could achieve a maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. During in vitro controlled drug releasing, the release efficiency was up to 92.20% within 24 h at T = 45 °C and pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems, and they were expected to play an essential role in the field of anticancer therapies.

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双反应羧甲基纤维素基纳米凝胶的合成及其给药应用

纳米凝胶由于其纳米级的尺寸，为生物偶联提供了较大的表面积，使血液循环时间延长，并靶向递送到特定组织。采用自由基聚合法制备了2-（2-（2-甲氧基乙氧基）乙氧基）甲基丙烯酸乙酯（MEO3MA）、甲基丙烯酸（MAA）和天然生物聚合物羧甲基纤维素（CMC）组成的CMC/POM纳米凝胶。采用多种技术表征了CMC/POM纳米凝胶的化学结构，并通过浊度和粒径的变化反映了CMC/POM纳米凝胶在温度和pH变化下的响应行为。结果表明，CMC/POM纳米凝胶在38°C和不同pH条件下的粒径和浊度变化显著。此外，CMC/POM纳米凝胶独特的微观结构使其有望通过注射治疗给药。以多柔比星（DOX）为模型药物，纳米凝胶的最大载药量为31.47%，载药效率为62.93%。体外控释时，在T = 45℃、pH = 3.0条件下，24h内释药效率可达92.20%。细胞毒性实验证实CMC/POM纳米凝胶具有良好的生物相容性，载药CMC/POM纳米凝胶能有效抑制癌细胞活性。CMC/POM纳米凝胶作为智能给药系统显示出巨大的潜力，有望在抗癌治疗领域发挥重要作用。图形抽象

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文献相关原料

公司名称

产品信息

阿拉丁

doxorubicin hydrochloride (DOX·HCl)

阿拉丁

N,N′-methylenebisacrylamide (MBA)

阿拉丁

ammonium persulfate ((NH4)2S2O8)

阿拉丁

Methacrylic acid (MAA)

来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.