Modeling Degradation Behavior of (Bio)Degradable Polymers for Medical Devices: A Comparative Review of Physio-chemical Approaches

IF 5 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL Journal of Polymers and the Environment Pub Date : 2024-11-25 DOI:10.1007/s10924-024-03376-5

Saeed Sanjari, Shahram Etemadi Haghighi, Payam Saraeian, Ali Alinia-ziazi

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Abstract

This review delves into the physio-chemical modeling of widely used (bio)degradable polymers such as polylactide (PLA), polyglycolide (PGA), and polycaprolactone (PCL), emphasizing the interplay between environmental conditions, chemical reactions, and material alterations. It utilizes structural equations and reaction–diffusion approaches to model changing structural properties during degradation. This review explores recent advances in physio-chemical modeling techniques, offering insights into predicting degradation kinetics, molecular weight evolution, and mass loss. This comprehensive understanding is essential for tailoring the degradation profiles of (bio)degradable polymers, optimizing their performance, and reducing environmental impact. Additionally, the review covers various other modeling approaches, including the multiscale method and the hybrid method, providing a holistic view of the current state of (bio)degradable polymer degradation modeling.

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医疗器械（生物）可降解聚合物的降解行为建模：理化方法的比较回顾

本综述深入研究了广泛使用的（生物）可降解聚合物，如聚乳酸（PLA），聚乙醇酸（PGA）和聚己内酯（PCL）的理化建模，强调了环境条件，化学反应和材料改变之间的相互作用。它利用结构方程和反应扩散方法来模拟降解过程中结构性质的变化。这篇综述探讨了理化建模技术的最新进展，为预测降解动力学、分子量演化和质量损失提供了见解。这种全面的理解对于定制（生物）可降解聚合物的降解特征、优化其性能和减少对环境的影响至关重要。此外，回顾了各种其他建模方法，包括多尺度方法和混合方法，提供了（生物）可降解聚合物降解建模的现状的整体视图。

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.