Resting-State Functional MRI Regional Homogeneity Correlates With Motor Scores in Parkinson's Disease

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2025-02-03 DOI:10.1111/jon.70020

Wei Dai, Zhe Li, Hao Lin, Yaoyun Kuang, Hengxu Mao, Tingting Gan, Jiaqi Wang, Pingyi Xu, Hongyan Li

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Abstract

Background and Purpose

This study investigated the neural mechanisms underlying Parkinson's disease (PD) subtypes—tremor dominant (TD) and postural instability gait difficulty (PIGD)—by analyzing regional homogeneity (ReHo) values from resting-state functional MRI.

Methods

Fifty-nine PD patients (29 TD patients, 30 PIGD patients) and 30 healthy controls (HCs) were enrolled. ReHo values were analyzed via analysis of variance and a two-sample t-test, with age and sex as covariates. Correlations between ReHo values and clinical motor symptoms were also examined.

Results

Distinct ReHo patterns were observed in patients with the PD subtypes and HCs. TD patients presented decreased ReHo in the cerebellar–thalamic–cortical circuit, whereas PIGD patients presented lower ReHo in the striatum and supplementary motor area (SMA). TD patients had higher ReHo in the bilateral dorsolateral superior frontal gyrus and SMA but lower ReHo in the bilateral medial orbital part of the superior frontal gyrus and other regions on the left than PIGD patients. Specific brain area ReHo values were correlated with tremor scores, PIGD scores, and rigidity scores.

Conclusion

Different motor subtypes of PD patients and HCs showed distinct ReHo patterns. ReHo correlation with clinical traits suggests its value as a biomarker for subtype-specific diagnostic strategies.

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!