Fabrication of an antifouling and acid/alkali-resistant sulfonated polyethersulfone (S-PES)/polysulfate (PSE) composite ultrafiltration membrane and its application in the desalination of ulinastatin

IF 2.4 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of chemical technology and biotechnology Pub Date : 2024-11-14 DOI:10.1002/jctb.7782

Wei Wang, Peipei Li, Jiaqi Wang, Baiyu Xu

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Abstract

BACKGROUND

An antifouling and acid/alkali-resistant sulfonated polyethersulfone (S-PES)/polysulfate (PSE) composite ultrafiltration (UF) membrane prepared via a nonsolvent-induced phase separation (NIPS) method was used for the purification of ulinastatin (UTI) as an examplar protein-based drug.

RESULT

The effect of the content of S-PES on the structure and UF performance of the S-PES/PSE composite UF membrane was investigated. The acid/alkaline resistance of the S-PES/PSE membranes was evaluated in the pH range 5–10 suitable for a UTI solution. UF desalination experiments were carried out on UTI elution collection solution, and the antifouling performance and long-term stability of S-PES/PSE composite UF membrane were evaluated. The results indicate that, for the optimal content of 4% S-PES, pure water flux increased from 120 to 726 L m⁻² h⁻¹, WCA decreased from 79.3° to 51.0°, and the rejection of UTI was 95.90% ± 1.1% compared to PSE. Compared with PES and PSF membranes, the flux recovery rate of the S-PES/PSE composite UF membrane was 80.63% (an increase of 32.48%), and the UTI adsorption was only 75.00 μg cm⁻² (a decrease of 88.00%) after simulated antifouling experiments.

CONCLUSION

The S-PES/PSE composite UF membrane has excellent long-term stability, suggesting significant potential for application in the purification of protein-based drugs and in large-scale UTI purification. © 2024 Society of Chemical Industry (SCI).

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防污耐酸碱磺化聚醚砜(S-PES)/聚硫酸盐（PSE）复合超滤膜的制备及其在乌司他丁脱盐中的应用

采用非溶剂诱导相分离（NIPS）法制备了一种防污耐酸碱的磺化聚醚砜(S-PES)/聚硫酸盐（PSE）复合超滤（UF）膜，用于纯化乌司他丁（UTI）。结果考察了S-PES/PSE复合超滤膜结构和超滤性能的影响。在适宜于UTI溶液的pH值5-10范围内，对S-PES/PSE膜的耐酸碱性进行了评价。采用UTI洗脱收集液进行超滤脱盐实验，对S-PES/PSE复合超滤膜的防污性能和长期稳定性进行了评价。结果表明，当S-PES含量为4%时，与PSE相比，纯水通量从120 L m−2 h−1增加到726 L m−2 h−1，WCA从79.3°降低到51.0°，UTI去除率为95.90%±1.1%。与PES和PSF膜相比，S-PES/PSE复合UF膜的通量回收率为80.63%（提高了32.48%），模拟防污实验表明，该膜对UTI的吸附仅为75.00 μg cm−2（降低了88.00%）。结论S-PES/PSE复合超滤膜具有良好的长期稳定性，在蛋白类药物纯化和大规模UTI纯化方面具有较大的应用潜力。©2024化学工业学会（SCI）。

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.