Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.

IF 4.8 2区医学 Q2 IMMUNOLOGY Frontiers in Cellular and Infection Microbiology Pub Date : 2025-01-20 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1501010

Saber Imani, Xiaoyan Li, Keyi Chen, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Saloomeh Khoushab, Xiaoping Li

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Abstract

Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have significantly enhanced the design, prediction, and optimization of mRNA vaccines. This paper reviews technologies that streamline mRNA vaccine development, from genomic sequencing to lipid nanoparticle (LNP) formulation. We discuss how accurate predictions of neoantigen structures guide the design of mRNA sequences that effectively target immune and cancer cells. Furthermore, we examine AI-driven approaches that optimize mRNA-LNP formulations, enhancing delivery and stability. These technological innovations not only improve vaccine design but also enhance pharmacokinetics and pharmacodynamics, offering promising avenues for personalized cancer immunotherapy.

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用于癌症免疫疗法的 mRNA 疫苗设计中的计算生物学和人工智能。

信使RNA （mRNA）疫苗为癌症免疫治疗提供了一个适应性强且可扩展的平台，需要优化设计以引发强大的靶向免疫反应。生物信息学和人工智能（AI）的最新进展显著增强了mRNA疫苗的设计、预测和优化。本文综述了简化mRNA疫苗开发的技术，从基因组测序到脂质纳米颗粒（LNP）配方。我们讨论了新抗原结构的准确预测如何指导有效靶向免疫和癌细胞的mRNA序列的设计。此外，我们研究了人工智能驱动的方法，优化mRNA-LNP配方，提高递送和稳定性。这些技术创新不仅改进了疫苗设计，而且增强了药代动力学和药效学，为个性化癌症免疫治疗提供了有希望的途径。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.