Electrochemical Difunctionalization of Alkenes.

Abstract

Owing to their wide utilizations in synthesis and their products prevalence in numerous natural products, pharmaceuticals and functional materials, the alkene difunctionalization methods for the selective transformations of the olefins are important and have attracted much attention form the synthetic chemists. Among them, the electrochemical alkene difunctionalization reaction is particularly promising and has becoming a potent and sustainable tool for the selective transformations of alkenes into vicinal difunctionalized structures in organic synthesis through simultaneous incorporation of two functional groups. Herein, we summarize recent progress in the electrochemical alkene difunctionalization reactions according to the alkene difunctionalization types as well as the category of the radicals over the past five years. By selecting the remarkable synthetic examples, we have elaborately discussed the substrate scope and the mechanisms for the electrochemical olefin difunctionalization reaction.