Aiping Zhang, Ruifeng Zhang, Yiling Jiang, Ling Shi, Meihong Luo
{"title":"Neglected adult PFAPA syndrome","authors":"Aiping Zhang, Ruifeng Zhang, Yiling Jiang, Ling Shi, Meihong Luo","doi":"10.1016/j.radcr.2025.01.051","DOIUrl":null,"url":null,"abstract":"<div><div>Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is rarely seen in adults. The diagnosis is challenging, and the majority of cases are misdiagnosed early. Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis or lymphadenitis and received multiple antibiotic therapy without any clinical benefit. This report emphasizes the importance of early identification of the disease. Patients with periodic fever accompanied by cervical lymphadenitis, clinicians should consider the possibility of PFAPA syndrome especially when antibiotic treatment is ineffective. The case showed that colchicine could significantly prolong the interval between fever, with the longest interval reaching 8 months, which significantly improved the patient's quality of life (QOL).</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 4","pages":"Pages 2116-2122"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1930043325000524","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome is rarely seen in adults. The diagnosis is challenging, and the majority of cases are misdiagnosed early. Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis or lymphadenitis and received multiple antibiotic therapy without any clinical benefit. This report emphasizes the importance of early identification of the disease. Patients with periodic fever accompanied by cervical lymphadenitis, clinicians should consider the possibility of PFAPA syndrome especially when antibiotic treatment is ineffective. The case showed that colchicine could significantly prolong the interval between fever, with the longest interval reaching 8 months, which significantly improved the patient's quality of life (QOL).
期刊介绍：
The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.
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