Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities

IF 6.7 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2025-01-20 DOI:10.1016/j.jsamd.2025.100853

Hui Yang , Cui Wang , Qingjiang Wang , Feng Han

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引用次数: 0

Abstract

A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's structural properties was conducted using FE-SEM, TEM, EDX, and XRD assays. The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. The HUVEC cell line was also used to evaluate the material's biocompatibility with normal cells. Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer.

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来源期刊

Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials

CiteScore

11.90

自引率

2.50%

发文量

审稿时长

47 days

期刊介绍： In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.