Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities

IF 6.8 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2025-06-01 Epub Date: 2025-01-20 DOI:10.1016/j.jsamd.2025.100853

Hui Yang , Cui Wang , Qingjiang Wang , Feng Han

{"title":"Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities","authors":"Hui Yang , Cui Wang , Qingjiang Wang , Feng Han","doi":"10.1016/j.jsamd.2025.100853","DOIUrl":null,"url":null,"abstract":"<div><div>A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's structural properties was conducted using FE-SEM, TEM, EDX, and XRD assays. The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. The HUVEC cell line was also used to evaluate the material's biocompatibility with normal cells. Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer.</div></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"10 2","pages":"Article 100853"},"PeriodicalIF":6.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Science: Advanced Materials and Devices","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468217925000061","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

A straightforward, efficient, and environmentally friendly method has been developed to synthesize gold nanoparticles (Au NPs) supported on kaolin with no harmful additives, ephedra flower extract acts as a biogenic stabilizing and reducing agent. An analysis of the Au NPs/Kaolin composite's structural properties was conducted using FE-SEM, TEM, EDX, and XRD assays. The biological activity of the composite was evaluated through cytotoxicity tests using the MTT assay. In addition, its potential anti-ovarian cancer properties were tested against several ovarian cancer cell lines, including TOV-21G, OV-90, SW 626, and UWB1.289, with IC50 values found to be 112, 250, 278, and 243 μg/mL, respectively. The ovarian cancer cell lines showed a dose-dependent decline in % cell viability. The HUVEC cell line was also used to evaluate the material's biocompatibility with normal cells. Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

高岭土上麻黄提取物介导的金纳米颗粒：一种天然的还原和稳定方法，具有抗氧化和抗卵巢癌活性的评价

一种简单、高效、环保的方法在不添加有害添加剂的情况下合成高岭土上的金纳米颗粒（Au NPs），麻黄花提取物具有生物稳定性和还原剂的作用。采用FE-SEM、TEM、EDX和XRD分析了Au NPs/高岭土复合材料的结构性能。通过使用MTT法进行细胞毒性试验，评估了复合材料的生物活性。此外，对TOV-21G、OV-90、SW 626和UWB1.289等卵巢癌细胞株进行了抑癌实验，IC50值分别为112、250、278和243 μg/mL。卵巢癌细胞系细胞活力呈剂量依赖性下降。用HUVEC细胞系评价材料与正常细胞的生物相容性。基于上述结果，该生物复合材料有望成为治疗人卵巢癌的一种治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials

CiteScore

11.90

自引率

2.50%

发文量

审稿时长

47 days

期刊介绍： In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.