Sarc-Global: a new sarcopenia screening tool in older adults

IF 3 3区医学 Q2 NUTRITION & DIETETICS Nutrition Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI:10.1016/j.nut.2024.112654

Natalia Correia Lopes MS , Ana Carolina Costa Vicedomini MS , Natália Vieira Magalhães MS , Dan Linetzky Waitzberg MD, PhD , Wilson Jacob MD , Alexandre Busse MD , Douglas Ferdinando MS , Rosa Maria Rodrigues Pereira MD , Raquel Torrinhas MD , Giliane Belarmino MD

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Abstract

Background

Sarcopenia is associated with clinical complications that increase mortality in older adults. Current screening tools, such as Sarc-F and Sarc-CalF, focus primarily on muscular performance but have limited sensitivity in identifying elderly individuals at risk of sarcopenia. The present study aims to develop a more comprehensive sarcopenia risk screening tool, Sarc-Global, which integrates additional anthropometric and clinical variables to enhance the sensitivity and accuracy of sarcopenia risk assessment in older adults.

Methods

The aim of this cross-sectional study was to develop a sarcopenia risk screening tool, named Sarc-Global, with enhanced sensitivity, incorporating factors pertinent to the overall health of elderly individuals. Utilizing the criteria established by EWGSOP2 for diagnosing sarcopenia, we evaluated 395 community-dwelling elderly individuals. This evaluation served as a reference for assessing the efficacy of two validated questionnaires, Sarc-F and Sarc-CalF, and our newly developed Sarc-Global.

Results

Multiple logistic regression revealed that Sarc-Global integrates variables such as sex, age, medication use, body mass index, arm circumference, and handgrip strength, which are significantly associated with sarcopenia (p<0.001). When combined with Sarc-CalF, these variables form the basis of the Sarc-Global model. In screening for sarcopenia risk, Sarc-Global demonstrated superior accuracy, specificity, and sensitivity (74%), outperforming Sarc-F (21%) and Sarc-CalF (34%).

Conclusion

Sarc-Global proves to be an effective tool for identifying elderly individuals at risk of sarcopenia.

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Sarc-Global：一种新的老年人肌肉减少症筛查工具

背景：骨骼肌减少症与增加老年人死亡率的临床并发症有关。目前的筛查工具，如Sarc-F和Sarc-CalF，主要关注肌肉表现，但在识别有肌少症风险的老年人方面灵敏度有限。本研究旨在开发一种更全面的肌少症风险筛查工具Sarc-Global，该工具整合了额外的人体测量和临床变量，以提高老年人肌少症风险评估的敏感性和准确性。方法本横断面研究的目的是开发一种名为Sarc-Global的肌肉减少症风险筛查工具，该工具具有增强的敏感性，并纳入与老年人整体健康相关的因素。利用EWGSOP2建立的诊断肌少症的标准，我们评估了395名社区居住的老年人。该评价可作为评价两份有效问卷（Sarc-F和Sarc-CalF）以及我们新开发的Sarc-Global的有效性的参考。结果多元logistic回归显示，Sarc-Global整合了性别、年龄、用药情况、体重指数、臂围、握力等变量，这些变量与肌肉减少症显著相关（p<0.001）。当与Sarc-CalF结合使用时，这些变量构成了Sarc-Global模型的基础。在筛查肌少症风险时，Sarc-Global显示出更高的准确性、特异性和敏感性（74%），优于Sarc-F（21%）和Sarc-CalF（34%）。结论sarc - global是识别老年肌少症高危人群的有效工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.