B. Chaithanya , D. Prabhakara Chary , Venkateshwara Rao Anna
{"title":"Synthesis and biological evaluation of chalcone incorporated thaizole-isoxazole derivatives as anticancer agents","authors":"B. Chaithanya , D. Prabhakara Chary , Venkateshwara Rao Anna","doi":"10.1016/j.cdc.2024.101177","DOIUrl":null,"url":null,"abstract":"<div><div>A new series of chalcone derivatives of thaizole-isoxazole derivatives (<strong>11a-j</strong>) and their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, all derivatives were investigated for their preliminary anticancer activity towards four human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) & A2780 (human ovarian cancer) by employing the MTT assay. Most of the tested compounds displayed remarkable anticancer activity compared to the positive control (etoposide). Among the various tested derivatives, five compounds <strong>11a,</strong> 11 g<strong>,</strong> 11 h<strong>, 11i</strong>&<strong>11j</strong> exhibited more potent activity. Particularly, one compound <strong>11j</strong> displayed the most promising activity (MCF-7 = 0.33 ± 0.085 µM; A549 = 0.12 ± 0.064 µM; Colo-205 = 0.77 ± 0.075 µM& A2780 = 0.93 ± 0.082 µM)..</div></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":"55 ","pages":"Article 101177"},"PeriodicalIF":2.2180,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S240583002400065X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
Abstract
A new series of chalcone derivatives of thaizole-isoxazole derivatives (11a-j) and their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, all derivatives were investigated for their preliminary anticancer activity towards four human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) & A2780 (human ovarian cancer) by employing the MTT assay. Most of the tested compounds displayed remarkable anticancer activity compared to the positive control (etoposide). Among the various tested derivatives, five compounds 11a, 11 g, 11 h, 11i&11j exhibited more potent activity. Particularly, one compound 11j displayed the most promising activity (MCF-7 = 0.33 ± 0.085 µM; A549 = 0.12 ± 0.064 µM; Colo-205 = 0.77 ± 0.075 µM& A2780 = 0.93 ± 0.082 µM)..
期刊介绍：
Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
