Traumatic lacerated lung with diffuse corpora amylacea; the wasteosomes of protection -case report and review of literature

Abstract

Corpora amylacea (CA) has been associated with ageing and various pathological disorders of different organs. Numerous hypotheses and postulates surrounding its origin and functions are available. We report here a case of a traumatic lacerated lung in a 49-year-old male with histopathological findings of diffuse corpora amylacea both intracellularly and extracellularly in the alveoli. The patient recuperated well post-surgical intervention. This case highlights corpora amylacea in the body’s defense and protective mechanism. It is unique as it is usually observed in autopsy findings, but we report these from a surgically resected lung as a management of trauma. It reiterates recent conjecture that these bodies are waste containers or wasteosomes, not only as a part of ageing but in various scenarios of oxidative stress, external factors which advertently activate the ubiquitin-proteasome degradation pathway.