Biofilm-state probiotics: Advanced alternatives to traditional probiotics

Abstract

Background

Probiotics have garnered significant attention for their potential to enhance human health. However, the challenge lies in their limited survival rates in harsh gastrointestinal environments, which hinders their therapeutic efficacy. Biofilm-state probiotics, characterized by enhanced stress resistance and colonization capabilities, offer a promising solution.

Scope and approach

This review comprehensively examines the biofilm formation process, influencing factors, and the advantages of biofilm-state probiotics. It delves into the intramembrane interactions and highlights the current understanding of their health benefits and innovative application methods.

Key findings and conclusions

Biofilm-state probiotics demonstrate superior persistence within human tissues, thereby sustaining their health-promoting functions. Employing molecular biology techniques and advanced biotechnological approaches can facilitate the development of novel, high-performance biofilm-state probiotics, addressing the colonization challenges faced by conventional probiotics.