{"title":"Hypothesized molecular mechanism of formation of membrano-cystic lesions","authors":"Toshitsugu Nakamura","doi":"10.1016/j.mehy.2024.111561","DOIUrl":null,"url":null,"abstract":"<div><div>Membrano-cystic lesions (MCLs) are characterized by undulating lipomembranous changes of lipid droplets and usually found in atherosclerotic lesions of aorta/arteries or in adipose tissues associated with panniculitis. MCLs are composed of lipid-carbohydrate-protein complexes (LCPCs), stable even in paraffin-embedded tissue sections, and are histochemically similar, but not identical, to lipofuscin and ceroid. Lipid peroxides damage carbohydrates and proteins, generating advanced glycation end products and advanced oxidative protein products that may play an important role in the formation of MCLs and lipofuscin/ceroid; MCLs are formed by deposition of oxidative LCPCs into lipid droplet membranes. The author proposes a speculative hypothesis that these deposits may change membrane stiffness/fluidity and impair lipid efflux/influx in various kinds of degree by a part, resulting in deformation of lipid droplets and MCL formation. As membrane stiffness/fluidity in unaffected cells varies according to cholesterol concentration or saturated/unsaturated form of lipids, qualitive/quantitative variety of molecular components of the droplets may contribute to the deformability to lipid droplets.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"195 ","pages":"Article 111561"},"PeriodicalIF":0.8000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724003049","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/31 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Membrano-cystic lesions (MCLs) are characterized by undulating lipomembranous changes of lipid droplets and usually found in atherosclerotic lesions of aorta/arteries or in adipose tissues associated with panniculitis. MCLs are composed of lipid-carbohydrate-protein complexes (LCPCs), stable even in paraffin-embedded tissue sections, and are histochemically similar, but not identical, to lipofuscin and ceroid. Lipid peroxides damage carbohydrates and proteins, generating advanced glycation end products and advanced oxidative protein products that may play an important role in the formation of MCLs and lipofuscin/ceroid; MCLs are formed by deposition of oxidative LCPCs into lipid droplet membranes. The author proposes a speculative hypothesis that these deposits may change membrane stiffness/fluidity and impair lipid efflux/influx in various kinds of degree by a part, resulting in deformation of lipid droplets and MCL formation. As membrane stiffness/fluidity in unaffected cells varies according to cholesterol concentration or saturated/unsaturated form of lipids, qualitive/quantitative variety of molecular components of the droplets may contribute to the deformability to lipid droplets.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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