A voltammetric sensor based on praseodymium oxide nanoparticles immobilized on tetrahedral boronate esters for favipiravir used in the treatment of COVID-19

IF 6.3 3区工程技术 Q1 ENGINEERING, CHEMICAL Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2025-04-01 Epub Date: 2025-01-25 DOI:10.1016/j.jtice.2025.105975

Hilal Incebay , Ahmet Kilic

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Abstract

Background

This research aims to develop a novel electrochemical sensor strategy from the nanocomposite obtained by incorporating praseodymium oxide nanoparticles (Pr_₆O_₁₁NPs) into tetrahedral boronate esters (BE_₁N) and to use this sensor for the accurate and sensitive detection of Favipiravir drug used in the treatment of COVID-19.

Method

BE1N, which our group previously synthesized, and Pr₆O₁₁NPs were subjected to sonication in chloroform to be completely catalyzed, and conductive Pr_₆O_₁₁NPs/BE_₁N nanocomposite suspension was obtained. Pr_₆O_₁₁NPs/BE_₁N nanocomposite suspension was immobilized on the surface of the polished glassy carbon electrode (GCE) by the drop drying method, and a working electrode defined as Pr_₆O_₁₁NPs/BE_₁N/GCE was obtained for electrochemical experiments.

Significant findings

Pr_₆O_₁₁NPs/BE_₁N/GCE was characterized and used to detect Favipiravir using the square wave voltammetry technique. Under optimal conditions, Pr_₆O_₁₁NPs/BE_₁N/GCE provided an LOD of 0.035 nM in a linear range of 1.0 nM to 20 μM for Favipiravir. Additionally, the nanovoltammetric sensor exhibited highly effective repeatability, reproducibility, and stability while demonstrating negligible performance interference against interfering species. Besides, it was confirmed that the proposed nanovoltammetric sensor could be used for the sensitive detection of Favipiravir in real samples such as pharmaceutical tablets, urine, and human blood serum.

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基于四面体硼酸酯固定氧化镨纳米颗粒的伏安传感器用于治疗COVID-19

本研究旨在将氧化镨纳米颗粒（Pr6O11NPs）与四面体硼酸酯（BE1N）结合得到的纳米复合材料开发一种新的电化学传感器策略，并利用该传感器准确灵敏地检测治疗COVID-19的药物Favipiravir。方法本课组前期合成的BE1N和Pr6O11NPs在氯仿中超声完全催化，得到导电的Pr6O11NPs/BE1N纳米复合悬浮液。采用滴干法将Pr6O11NPs/BE1N纳米复合悬浮液固定在抛光玻碳电极（GCE）表面，得到工作电极Pr6O11NPs/BE1N/GCE进行电化学实验。对spr6o11nps /BE1N/GCE进行了表征，并使用方波伏安法检测Favipiravir。在最佳条件下，在1.0 nM ~ 20 μM的线性范围内，Pr6O11NPs/BE1N/GCE对Favipiravir的LOD为0.035 nM。此外，纳米伏安传感器表现出高度有效的重复性、再现性和稳定性，同时对干扰物质的性能干扰可以忽略不计。此外，该纳米伏安传感器可用于药片、尿液和人血清等实际样品中Favipiravir的灵敏检测。

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来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.