Effectiveness and Safety of Blending Traditional Chinese Medicine With Western Medicine for Enhanced Secondary Stroke Prevention: A Meta-analysis of RCTs

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Herbal Medicine Pub Date : 2025-02-01 DOI:10.1016/j.hermed.2024.100953
C.L. Wen , L.-J. Song , C.-G. Ma , Z.-X. Su , F.-Y. Hu , L.-Q. Zhu
{"title":"Effectiveness and Safety of Blending Traditional Chinese Medicine With Western Medicine for Enhanced Secondary Stroke Prevention: A Meta-analysis of RCTs","authors":"C.L. Wen ,&nbsp;L.-J. Song ,&nbsp;C.-G. Ma ,&nbsp;Z.-X. Su ,&nbsp;F.-Y. Hu ,&nbsp;L.-Q. Zhu","doi":"10.1016/j.hermed.2024.100953","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>To conduct a comprehensive evaluation of the efficacy and safety of combining traditional Chinese medication (TCM) with Western medication to improve secondary stroke prevention. Through meticulous analysis, we investigate the combined approach's potential to yield superior outcomes compared to stand-alone Western medical treatments.</div></div><div><h3>Methods</h3><div>We rigorously searched for RCTs on secondary stroke prevention using TCM and Western medicine (WM) from database creation to October 2023. PubMed, EMBASE, Cochrane Library, CNKI, SinoMed, WanFang, and VIP yielded pertinent studies. Stata 16.0 was used for comprehensive meta-analyses with predetermined inclusion and exclusion criteria.</div></div><div><h3>Results</h3><div>This thorough review comprised 40 randomised controlled trials with 3 478 treatment and 3 396 control participants. Combining TCM and WM significantly enhances secondary stroke prevention rates compared to WM alone (OR = 0.83, 95% CI: 0.55–1.12, <em>P</em> &lt; 0.001). Compared to Western medical treatment for secondary stroke prevention, the integrated strategy significantly lowered the National Institutes of Health Stroke Scale score (OR = -0.62, 95% CI: -0.89, -0.35, <em>P</em> &lt; 0.001). Furthermore, this integrated strategy effectively reduced stroke recurrence rates compared to Western medical therapy alone (OR = -0.94, 95% CI: -1.10, -0.76, <em>P</em> &lt; 0.001). The rate of adverse reactions was not significantly different between Western medical treatment and integrated TCM (OR = 0.01, 95% CI: −0.18, 0.05, <em>P</em> = 0.131).</div></div><div><h3>Conclusions</h3><div>The evidence shows that combining TCM and Western therapy improves secondary stroke prevention. Besides improving clinical effectiveness, this integrated approach may reduce stroke recurrence. These findings strongly support the widespread use of this integrated approach in clinical practice.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"49 ","pages":"Article 100953"},"PeriodicalIF":2.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324001106","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

To conduct a comprehensive evaluation of the efficacy and safety of combining traditional Chinese medication (TCM) with Western medication to improve secondary stroke prevention. Through meticulous analysis, we investigate the combined approach's potential to yield superior outcomes compared to stand-alone Western medical treatments.

Methods

We rigorously searched for RCTs on secondary stroke prevention using TCM and Western medicine (WM) from database creation to October 2023. PubMed, EMBASE, Cochrane Library, CNKI, SinoMed, WanFang, and VIP yielded pertinent studies. Stata 16.0 was used for comprehensive meta-analyses with predetermined inclusion and exclusion criteria.

Results

This thorough review comprised 40 randomised controlled trials with 3 478 treatment and 3 396 control participants. Combining TCM and WM significantly enhances secondary stroke prevention rates compared to WM alone (OR = 0.83, 95% CI: 0.55–1.12, P < 0.001). Compared to Western medical treatment for secondary stroke prevention, the integrated strategy significantly lowered the National Institutes of Health Stroke Scale score (OR = -0.62, 95% CI: -0.89, -0.35, P < 0.001). Furthermore, this integrated strategy effectively reduced stroke recurrence rates compared to Western medical therapy alone (OR = -0.94, 95% CI: -1.10, -0.76, P < 0.001). The rate of adverse reactions was not significantly different between Western medical treatment and integrated TCM (OR = 0.01, 95% CI: −0.18, 0.05, P = 0.131).

Conclusions

The evidence shows that combining TCM and Western therapy improves secondary stroke prevention. Besides improving clinical effectiveness, this integrated approach may reduce stroke recurrence. These findings strongly support the widespread use of this integrated approach in clinical practice.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
期刊最新文献
Survey Exploration of Some Plants Used in Managing Hypertension in the North Central States of Nigeria Determination of Antimicrobial, Antioxidant and Phenolic Properties of Onobrychis silvanensis sp. Nov. Endemic Species Traditional herbal practices associated with malaria and symptoms: Mishmi tribe cohort study from Arunachal Pradesh, Northeast India Ethnomedicinal Plants Used for Skin Care in Sirmour District of Himachal Pradesh (India) Efficacy of traditional Chinese medicine combined with conventional western medicine on metabolic syndrome: a Bayesian network meta-analysis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1