Collaborating across sectors in service of open science, precision oncology, and patients: an overview of the AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC)

A. Acebedo , P.L. Bedard , S. Brown , E. Ceca , M. Fiandalo , H. Fuchs , X. Guo , J.N. Hoppe , K.L. Kehl , R. Kundra , J.A. Lavery , M.L. LeNoue-Newton , E. Lepisto , B. Mastrogiacomo , C.M. Micheel , C. Nayan , A. Newcomb , C. Nichols , K.S. Panageas , B. Piening , C. Yu
{"title":"Collaborating across sectors in service of open science, precision oncology, and patients: an overview of the AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC)","authors":"A. Acebedo ,&nbsp;P.L. Bedard ,&nbsp;S. Brown ,&nbsp;E. Ceca ,&nbsp;M. Fiandalo ,&nbsp;H. Fuchs ,&nbsp;X. Guo ,&nbsp;J.N. Hoppe ,&nbsp;K.L. Kehl ,&nbsp;R. Kundra ,&nbsp;J.A. Lavery ,&nbsp;M.L. LeNoue-Newton ,&nbsp;E. Lepisto ,&nbsp;B. Mastrogiacomo ,&nbsp;C.M. Micheel ,&nbsp;C. Nayan ,&nbsp;A. Newcomb ,&nbsp;C. Nichols ,&nbsp;K.S. Panageas ,&nbsp;B. Piening ,&nbsp;C. Yu","doi":"10.1016/j.esmorw.2024.100097","DOIUrl":null,"url":null,"abstract":"<div><div>The American Association for Cancer Research (AACR) Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC) is a multi-phase, pre-competitive collaboration between 10 biopharmaceutical companies and select GENIE-participating academic institutions, focused on detailed clinical annotations of a subset of patients within the GENIE Registry. The cohorts focus on 10 solid tumors, and each integrates demographic, diagnosis, genomic, and treatment data with longitudinal, real-world patient outcomes. Data are collected following a structured framework to ensure interoperability and forward compatibility with other data models. Each cohort undergoes a series of rigorous quality control and assurance protocols which ensures consistency, accuracy, and reliability of the data across multiple institutions before public release of the data. Initial analyses of the BPC data have yielded valuable insights, including the validation of treatment-induced resistance mutations and genomic drivers associated with anatomic sites of metastasis. Additionally, the real-world response endpoints compare favorably to published trial results. Central management and a shared knowledgebase help integrate diverse functional teams in the execution of a complex, multi-institutional data collection effort. Future directions aim to automate significant portions of the clinical annotation process to collect clinical data at scale. These efforts will increase the depth and granularity of the BPC data, as well as expand the overall cohort size and range of cancer types represented.</div></div>","PeriodicalId":100491,"journal":{"name":"ESMO Real World Data and Digital Oncology","volume":"7 ","pages":"Article 100097"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ESMO Real World Data and Digital Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949820124000754","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The American Association for Cancer Research (AACR) Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC) is a multi-phase, pre-competitive collaboration between 10 biopharmaceutical companies and select GENIE-participating academic institutions, focused on detailed clinical annotations of a subset of patients within the GENIE Registry. The cohorts focus on 10 solid tumors, and each integrates demographic, diagnosis, genomic, and treatment data with longitudinal, real-world patient outcomes. Data are collected following a structured framework to ensure interoperability and forward compatibility with other data models. Each cohort undergoes a series of rigorous quality control and assurance protocols which ensures consistency, accuracy, and reliability of the data across multiple institutions before public release of the data. Initial analyses of the BPC data have yielded valuable insights, including the validation of treatment-induced resistance mutations and genomic drivers associated with anatomic sites of metastasis. Additionally, the real-world response endpoints compare favorably to published trial results. Central management and a shared knowledgebase help integrate diverse functional teams in the execution of a complex, multi-institutional data collection effort. Future directions aim to automate significant portions of the clinical annotation process to collect clinical data at scale. These efforts will increase the depth and granularity of the BPC data, as well as expand the overall cohort size and range of cancer types represented.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Clinical decision impact of HER2DX, an algorithm-powered genomic diagnostic in early-stage HER2-positive breast cancer: results from a prospective real-world study Core variables for real-world clinicogenomic data collection in precision oncology Cancer in public figures, 2010-2020 Definitions, measurement, and reporting of progression-free survival in randomized clinical trials and observational studies of patients with advanced non-small-cell lung cancer treated with immunotherapy: a scoping review Guidelines and variations in patterns of GnRH analogue use in castration-resistant prostate cancer across six countries
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1