EEG signature orchestrating expression of ictal behavior in mesial temporal lobe epilepsy

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-01-24 DOI:10.1016/j.clinph.2024.12.029

Chenmin He , Wenhan Hu , Kai Xiong , Lingqi Ye , Hongyi Ye , Lingli Hu , Yi Ge , Meng Wang , Cong Chen , Bo Jin , Cenglin Xu , Yi Wang , Sha Xu , Yao Ding , Yingcai Wu , Hongjie Jiang , Junming Zhu , Meiping Ding , Wenling Li , Kai Zhang , Shan Wang

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Abstract

Objectives

We investigated EEG features differentiating clinical seizures (CSs) from subclinical seizures (SCSs) to explore the mechanisms underlying the generation of ictal behavior in mesial temporal lobe epilepsy (mTLE).

Methods

Peri-ictal state of power spectral density (PSD) within seizure onset zone (SOZ) and propagation zone (PZ) were compared between SCSs and CSs. Functional connectivity was analyzed using the nonlinear correlation coefficient h², outgoing links (OUT) and ingoing links (IN). The EEG epochs of CSs-early part and SCSs were equally divided into four segments to reveal dynamic EEG changes.

Results

During pre-ictal state, PSD at 30–80 Hz in SOZ was higher in CSs than in SCSs. The preictal OUT and IN values in SOZ at 30–80 Hz were greater in CSs than in SCSs. During CSs-early part, PSD displayed an initial increase in SOZ but a late increase in PZ, with enhanced high-frequency activity in temporal regions and increased low-frequency activity in insula.

Conclusion

The enhanced pre-ictal gamma activity within the epileptic network was able to distinguish CSs from SCSs. The unique temporospatial alterations within the epileptic network drive the expression of ictal behavior in mTLE.

Significance

The distinct EEG features between SCSs and CSs offer transformative insights into the mechanisms driving ictal behavior.

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内侧颞叶癫痫发作行为的脑电图特征协调表达

目的研究区分临床癫痫发作（CSs）和亚临床癫痫发作（SCSs）的脑电图特征，探讨中颞叶癫痫（mTLE）发作行为产生的机制。方法比较两组癫痫发作区（SOZ）和传播区（PZ）功率谱密度（PSD）的生理状态。利用非线性相关系数h2、输出链路（OUT）和输入链路（IN）分析功能连通性。将css -早期和scs的脑电时代平均分为4段，以显示脑电的动态变化。结果在昏迷前状态下，SOZ组30 ~ 80hz的PSD明显高于scs组。30-80 Hz时SOZ的预测OUT和IN值在CSs中大于scs。在css -早期，PSD表现出SOZ的初始增加，而PZ的后期增加，颞区高频活动增强，岛区低频活动增加。结论在癫痫网络中增强的峰前γ活动能够区分CSs和scs。癫痫网络中独特的时空变化驱动了mTLE中临界行为的表达。意义：scs和CSs之间不同的EEG特征为驱动临界行为的机制提供了变革性的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.