Brain network modulation in response to directional and Non-Directional Cues: Insights from EEG connectivity and graph theory

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI:10.1016/j.clinph.2025.01.007

Fabrizio Vecchio , Francesca Miraglia , Chiara Pappalettera , Paolo Maria Rossini

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Abstract

Objective

Directional cues have a profound impact on cognitive processes and behavior, and studying the involved brain networks can provide insights into their processing. This research aimed to investigate the neural network modulation associated with cognitive processing after the administration of directional cues using connectivity and graph theory.

Methods

Twenty healthy volunteers were enrolled and underwent EEG recording while they were asked to perform a visuomotor task, such as directional (DS) and non-directional (nDS). From EEG data, network parameters such as Small-World (SW) and Lagged linear connectivity across different EEG frequency bands were evaluated, analyzing the response to DS and nDS.

Results

The results revealed significant differences in the SW index, particularly in the Alpha 1 band, where participants exhibited a higher SW index when presented with DS compared to nDS. Moreover, the analysis of Alpha 1 band Lagged linear connectivity revealed close to statistically significant differences predominantly in the frontal and central regions.

Conclusions

This research contributes to our understanding of the neural mechanisms underlying the processing of directional cues.

Significance

It has potential implications for rehabilitation settings, for example in the rehabilitation of visual dysfunction and motor impairment following a stroke, by optimizing cognitive processing to enhance functional outcomes.

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脑网络调制对定向和非定向线索的响应：来自脑电图连接和图论的见解

目的：定向线索对认知过程和行为有深远的影响，研究其相关的大脑网络可以为其加工提供新的思路。本研究旨在利用连通性和图论探讨方向线索处理后与认知加工相关的神经网络调节。方法选取20名健康志愿者，在进行定向和非定向视觉运动任务时进行脑电图记录。根据脑电数据，评估不同脑电频段的小世界（SW）和滞后线性连通性等网络参数，分析对DS和nDS的响应。结果研究结果显示，两组受试者的SW指数存在显著差异，特别是在Alpha - 1波段，受试者在出现DS时的SW指数高于非DS。此外，α 1波段滞后线性连通性分析显示，主要在额叶和中央区域存在接近统计学意义的差异。结论本研究有助于我们理解方向线索加工的神经机制。它对康复环境有潜在的影响，例如，通过优化认知加工来增强功能结果，在中风后的视觉功能障碍和运动障碍的康复中。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.