Nutritional composition, toxicity, and the effects of Parkia biglobosa on the metabolic, somatic and oxidative parameters related to liver and kidney function of obese rats

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Functional Foods Pub Date : 2025-01-01 DOI:10.1016/j.jff.2024.106479

Mirela Gouveia-Nhanca , Maria Luiza Rolim Bezerra , Yuri Mangueira do Nascimento , Evandro Ferreira da Silva , Josean Fechine Tavares , Gonçalo Mendes da Conceição , Rubens Teixeira de Queiroz , Luis António Tavares , Adriano Francisco Alves , Jailane de Souza Aquino

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Abstract

Background

The pathophysiology of obesity is associated with somatic, metabolic and oxidative changes which can also compromise renal and hepatic function. Treatment of this condition involves dietary intervention, including incorporating foods rich in bioactive compounds such as Parkia biglobosa. This legume is rich in fibres and phenolic compounds such as 3,4-dihydroxybenzoic acid, catechin, and myricetin that can play a significant role in the adjuvant treatment of obesity. Thus, we evaluated the nutritional composition, toxicity, and the effects of Parkia biglobosa on metabolic, somatic and oxidative parameters, as well as the liver and kidney function of obese rats.

Methods

Parkia biglobosa pulp was initially characterised and evaluated for its toxicity. Then, male Wistar rats were randomised into groups: healthy (HG); obese (OG); healthy (HPB) and obese (OPB) both treated with Parkia biglobosa (400 mg/kg). Somatic and biochemical parameters; triglyceride, cholesterol and total fat in faeces and liver; oxidative and histological parameters in the liver and kidney were all analysed. Results: Parkia biglobosa intake reduced the adiposity index; improved glucose tolerance, insulin resistance, leptinemia and lipid metabolism parameters, which impacted the minimization of hepatic steatosis and improved oxidative parameters in the kidney and liver in obese rats (OPB). These findings are related to the nutritional composition of this legume, such as the relationship between insoluble and soluble fibres, as well as the phenolic and mineral profile.

Conclusion

The set of results showed that Parkia biglobosa had an anti-adiposity effect, improved biochemical including hormonal parameters and reversed the changes in hepatic and renal markers in obesity-induced rats.

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营养成分、毒性及其对肥胖大鼠肝肾功能相关代谢、躯体和氧化参数的影响

肥胖的病理生理与躯体、代谢和氧化变化有关，这些变化也可能损害肾功能和肝功能。这种疾病的治疗包括饮食干预，包括加入富含生物活性化合物的食物，如大叶Parkia。这种豆科植物富含纤维和酚类化合物，如3,4-二羟基苯甲酸、儿茶素和杨梅素，可在肥胖辅助治疗中发挥重要作用。因此，我们评估了营养成分，毒性，以及对肥胖大鼠的代谢，体细胞和氧化参数以及肝肾功能的影响。方法对白鹤牙髓进行初步表征，并对其毒性进行评价。然后，雄性Wistar大鼠随机分为两组：健康（HG）；肥胖(OG);健康（HPB）和肥胖（OPB）均给予大叶Parkia （400 mg/kg）。体细胞生化参数；粪便和肝脏中的甘油三酯、胆固醇和总脂肪；分析肝脏和肾脏的氧化和组织学参数。结果：大叶枇杷摄取量降低了肥胖指数；改善了葡萄糖耐量、胰岛素抵抗、瘦素血症和脂质代谢参数，从而影响了肥胖大鼠（OPB）肝脂肪变性的最小化，并改善了肾脏和肝脏的氧化参数。这些发现与这种豆科植物的营养成分有关，如不溶性纤维和可溶性纤维之间的关系，以及酚类和矿物质的分布。结论大白粉具有抗肥胖作用，能改善肥胖大鼠体内激素等生化指标，逆转肝脏和肾脏指标的变化。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.