Xiuqian Ding , Yong Wang , Jingxi Nan , Xue Wu , Xin Zhou
{"title":"Synthesis of phosphate-substituted near-infrared dyes for photoacoustic imaging and photothermal therapy","authors":"Xiuqian Ding , Yong Wang , Jingxi Nan , Xue Wu , Xin Zhou","doi":"10.1016/j.dyepig.2025.112663","DOIUrl":null,"url":null,"abstract":"<div><div>Photothermal therapy (PTT) can effectively ablate hypoxic tumors in deep issue under the near-infrared (NIR) irradiation. The development of novel NIR photothermal agents with high molar absorption coefficient and photothermal conversion efficiency is highly demanded. In this work, two phosphate-substituted xanthene dyes (<strong>POM</strong> and <strong>P7</strong>) were synthesized, and their stability and photothermal conversion efficiency were investigated. Both of them showed board absorption around 700 nm in the aqueous solution. In comparison with the rigid <strong>POM</strong>, <strong>P7</strong> with flexible and twisted core displayed a higher photothermal conversion efficiency. The nanoparticle encapsulated in amphiphilic polymers (<strong>P7 NPs</strong>) was further used in the photoacoustic imaging-guided photothermal therapy <em>in vivo</em>.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"236 ","pages":"Article 112663"},"PeriodicalIF":4.1000,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143720825000336","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Photothermal therapy (PTT) can effectively ablate hypoxic tumors in deep issue under the near-infrared (NIR) irradiation. The development of novel NIR photothermal agents with high molar absorption coefficient and photothermal conversion efficiency is highly demanded. In this work, two phosphate-substituted xanthene dyes (POM and P7) were synthesized, and their stability and photothermal conversion efficiency were investigated. Both of them showed board absorption around 700 nm in the aqueous solution. In comparison with the rigid POM, P7 with flexible and twisted core displayed a higher photothermal conversion efficiency. The nanoparticle encapsulated in amphiphilic polymers (P7 NPs) was further used in the photoacoustic imaging-guided photothermal therapy in vivo.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
