Clinical phenotypes and associated factors in knee osteoarthritis in an African black population

Osteoarthritis and cartilage open Pub Date : 2025-01-29 DOI:10.1016/j.ocarto.2025.100570

Charles Sougué , Malick Diallo , Yannick Laurent Tchenadoyo Bayala , Ismaël Ayouba Tinni , Fulgence Kaboré , Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo , Patrick Wendpouiré Hamed Dakouré , Dieu-Donné Ouedraogo

{"title":"Clinical phenotypes and associated factors in knee osteoarthritis in an African black population","authors":"Charles Sougué , Malick Diallo , Yannick Laurent Tchenadoyo Bayala , Ismaël Ayouba Tinni , Fulgence Kaboré , Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo , Patrick Wendpouiré Hamed Dakouré , Dieu-Donné Ouedraogo","doi":"10.1016/j.ocarto.2025.100570","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.</div></div><div><h3>Methods</h3><div>This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.</div></div><div><h3>Results</h3><div>A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034).</div></div><div><h3>Conclusion</h3><div>The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100570"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteoarthritis and cartilage open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2665913125000068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.

Methods

This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.

Results

A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034).

Conclusion

The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.

查看原文