Osteoarthritis and cartilage open最新文献

Acknowledgement to Reviewers 2024

Osteoarthritis and cartilage open

Pub Date : 2025-02-15 DOI: 10.1016/j.ocarto.2025.100581

引用次数: 0

Kellgren-Lawrence grading of knee osteoarthritis using deep learning: Diagnostic performance with external dataset and comparison with four readers

Osteoarthritis and cartilage open

Pub Date : 2025-02-07 DOI: 10.1016/j.ocarto.2025.100580

Elias Vaattovaara , Egor Panfilov , Aleksei Tiulpin , Tuukka Niinimäki , Jaakko Niinimäki , Simo Saarakkala , Mika T. Nevalainen

Objective

To evaluate the performance of a deep learning (DL) model in an external dataset to assess radiographic knee osteoarthritis using Kellgren-Lawrence (KL) grades against versatile human readers.

Materials and methods

Two-hundred-eight knee anteroposterior conventional radiographs (CRs) were included in this retrospective study. Four readers (three radiologists, one orthopedic surgeon) assessed the KL grades and consensus grade was derived as the mean of these. The DL model was trained using all the CRs from Multicenter Osteoarthritis Study (MOST) and validated on Osteoarthritis Initiative (OAI) dataset and then tested on our external dataset. To assess the agreement between the graders, Cohen's quadratic kappa (k) with 95 % confidence intervals were used. Diagnostic performance was measured using confusion matrices and receiver operating characteristic (ROC) analyses.

Results

The multiclass (KL grades from 0 to 4) diagnostic performance of the DL model was multifaceted: sensitivities were between 0.372 and 1.000, specificities 0.691–0.974, PPVs 0.227–0.879, NPVs 0.622–1.000, and AUCs 0.786–0.983. The overall balanced accuracy was 0.693, AUC 0.886, and kappa 0.820. If only dichotomous KL grading (i.e. KL0-1 vs. KL2-4) was utilized, superior metrics were seen with an overall balanced accuracy of 0.902 and AUC of 0.967. A substantial agreement between each reader and DL model was found: the inter-rater agreement was 0.737 [0.685–0.790] for the radiology resident, 0.761 [0.707–0.816] for the musculoskeletal radiology fellow, 0.802 [0.761–0.843] for the senior musculoskeletal radiologist, and 0.818 [0.775–0.860] for the orthopedic surgeon.

Conclusion

In an external dataset, our DL model can grade knee osteoarthritis with diagnostic accuracy comparable to highly experienced human readers.

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引用次数: 0

Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort

Osteoarthritis and cartilage open

Pub Date : 2025-02-05 DOI: 10.1016/j.ocarto.2025.100573

Alix Charton , Romane Lacoste-Badie , Sophie Tuffet , Alexandra Rousseau , Emmanuel Maheu , Bruno Fautrel , Maxime Dougados , Francis Berenbaum , Alice Courties , Jérémie Sellam

Background

The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA.

Methods

Using the DIGICOD cohort, 352 HOA patients (85 % women, mean age 66.4 ± 7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 % confidence intervals (CI).

Results

MetS was present in 36 % of patients and associated with higher pain levels during activity (VAS OR = 1.61, 95 % CI 1.02–2.57) and overall OA pain (AIMS2 OR = 1.85, 95 % CI 1.14–2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR = 1.66, 95 % CI 1.05–2.62), but significance was reduced when adjusting for HAD (OR = 1.56, 95 % CI 0.98–2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR = 2.58, 95 % CI 1.09–6.07). BMI was not found to be independently associated with pain.

Conclusion

MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.

{"title":"Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort","authors":"Alix Charton , Romane Lacoste-Badie , Sophie Tuffet , Alexandra Rousseau , Emmanuel Maheu , Bruno Fautrel , Maxime Dougados , Francis Berenbaum , Alice Courties , Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100573","DOIUrl":"10.1016/j.ocarto.2025.100573","url":null,"abstract":"<div><h3>Background</h3><div>The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA.</div></div><div><h3>Methods</h3><div>Using the DIGICOD cohort, 352 HOA patients (85 % women, mean age 66.4 ± 7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>MetS was present in 36 % of patients and associated with higher pain levels during activity (VAS OR = 1.61, 95 % CI 1.02–2.57) and overall OA pain (AIMS2 OR = 1.85, 95 % CI 1.14–2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR = 1.66, 95 % CI 1.05–2.62), but significance was reduced when adjusting for HAD (OR = 1.56, 95 % CI 0.98–2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR = 2.58, 95 % CI 1.09–6.07). BMI was not found to be independently associated with pain.</div></div><div><h3>Conclusion</h3><div>MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100573"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of quality indicators for hand osteoarthritis care – Results from an European consensus study

Osteoarthritis and cartilage open

Pub Date : 2025-02-05 DOI: 10.1016/j.ocarto.2025.100578

Daniel H. Bordvik , Yeliz Prior , Rachael Bamford , Francis Berenbaum , Mathilda Björk , Thalita Blanck , Barbara Slatkowsky Christensen , Krysia Dziedzic , John Edwards , Nazemin Gilanliogullari , Carol Graham , Ida K. Haugen , Margreet Kloppenburg , Hellen Laheij , Marco J.P.F. Ritt , Tanja Stamm , Anne Therese Tveter , Nina Østerås , Ingvild Kjeken

Background

People with hand osteoarthritis (OA) often have poor access to recommended treatments. To enhance care quality, quality indicators (QIs) based on clinical recommendations are essential. Current QI sets, like the Osteoarthritis Quality Indicator Questionnaire (OA-QI v.2), primarily address hip- and knee OA, and not hand OA.

Objectives

To adapt the OA-QI v.2 for assessing patient-reported quality of hand OA care.

Design

We used the OA-QI v.2. set as a starting point and adapted it to reflect hand OA care. A literature search was performed to identify potential QIs for hand OA following the Rand/UCLA Appropriateness method. A European expert panel, comprising researchers, clinicians, and patient research partners, participated in online meetings to discuss adaptation and suggest new QIs based on treatment recommendations for hand OA, and anonymously rated each suggested QI regarding its importance, validity, usefulness, and feasibility. Consensus was defined by predefined rating cut-off scores. The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity.

Results

Our initial literature search provided 1670 articles, with none describing relevant QIs. After three voting rounds, sixteen QI items reached consensus, reflecting current hand OA care standards. Items were generally well understood, requiring only minor clarity amendments after patient interviews (N = 28).

Conclusion

The OA-QI v.2 was successfully adapted into a 16-item Hand OA-QI set ensuring alignment with international care standards for hand OA through literature review, international expert panels and patient feedback on language and layout.

{"title":"Development of quality indicators for hand osteoarthritis care – Results from an European consensus study","authors":"Daniel H. Bordvik , Yeliz Prior , Rachael Bamford , Francis Berenbaum , Mathilda Björk , Thalita Blanck , Barbara Slatkowsky Christensen , Krysia Dziedzic , John Edwards , Nazemin Gilanliogullari , Carol Graham , Ida K. Haugen , Margreet Kloppenburg , Hellen Laheij , Marco J.P.F. Ritt , Tanja Stamm , Anne Therese Tveter , Nina Østerås , Ingvild Kjeken","doi":"10.1016/j.ocarto.2025.100578","DOIUrl":"10.1016/j.ocarto.2025.100578","url":null,"abstract":"<div><h3>Background</h3><div>People with hand osteoarthritis (OA) often have poor access to recommended treatments. To enhance care quality, quality indicators (QIs) based on clinical recommendations are essential. Current QI sets, like the Osteoarthritis Quality Indicator Questionnaire (OA-QI v.2), primarily address hip- and knee OA, and not hand OA.</div></div><div><h3>Objectives</h3><div>To adapt the OA-QI v.2 for assessing patient-reported quality of hand OA care.</div></div><div><h3>Design</h3><div>We used the OA-QI v.2. set as a starting point and adapted it to reflect hand OA care. A literature search was performed to identify potential QIs for hand OA following the Rand/UCLA Appropriateness method. A European expert panel, comprising researchers, clinicians, and patient research partners, participated in online meetings to discuss adaptation and suggest new QIs based on treatment recommendations for hand OA, and anonymously rated each suggested QI regarding its importance, validity, usefulness, and feasibility. Consensus was defined by predefined rating cut-off scores. The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity.</div></div><div><h3>Results</h3><div>Our initial literature search provided 1670 articles, with none describing relevant QIs. After three voting rounds, sixteen QI items reached consensus, reflecting current hand OA care standards. Items were generally well understood, requiring only minor clarity amendments after patient interviews (N = 28).</div></div><div><h3>Conclusion</h3><div>The OA-QI v.2 was successfully adapted into a 16-item Hand OA-QI set ensuring alignment with international care standards for hand OA through literature review, international expert panels and patient feedback on language and layout.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100578"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The associations between sleep problems and pain outcomes in people with hand osteoarthritis – Data from the Nor-hand study

Osteoarthritis and cartilage open

Pub Date : 2025-02-05 DOI: 10.1016/j.ocarto.2025.100579

Daniel H. Bordvik , Pernille Steen Pettersen , Marthe Gløersen , Elisabeth Mulrooney , Tuhina Neogi , Ingvild Kjeken , Ida K. Haugen

Objective

To examine the relation of sleep problems to pain outcomes in people with hand osteoarthritis, and the extent to which central sensitization mediates these relationships.

Design

In total 299 participants from the Nor-Hand cohort study rated their sleep problems (no, slight, moderate or severe problems), hand pain intensity on a Numeric Rating Scale (NRS, range: 0–10) and Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range: 0–20), and overall bodily pain intensity (NRS). Central sensitization was evaluated by quantitative sensory testing. All pain questionnaires were repeated after 3.5 years. We explored the associations between sleep problems at baseline and pain outcomes at baseline and follow-up and fitted natural effect models to examine the extent to which measures of central sensitization mediated the effects of sleep problems on pain. All main analyses were adjusted for age, sex, education, comorbidities, and body mass index.

Results

Slight, moderate, and severe sleep problems were reported by 33.8 %, 26.8 % and 14.3 %, respectively. In general, individuals with severe versus without sleep problems reported relatively more intense pain at baseline and follow up (i.e., a 1.68 (95 % confidence interval 0.89–2.46) higher NRS hand pain at baseline). Associations between sleep and central sensitization were weak, with no mediating effects found. For example, the indirect effect of remote pressure pain thresholds was 0.06 (−0.27, 0.39) NRS points for hand pain among individuals reporting severe sleep problems.

Conclusion

Sleep problems are commonly reported and related to pain intensity in people with hand osteoarthritis, while the underlying mechanisms and temporal relationship remain unclear.

{"title":"The associations between sleep problems and pain outcomes in people with hand osteoarthritis – Data from the Nor-hand study","authors":"Daniel H. Bordvik , Pernille Steen Pettersen , Marthe Gløersen , Elisabeth Mulrooney , Tuhina Neogi , Ingvild Kjeken , Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100579","DOIUrl":"10.1016/j.ocarto.2025.100579","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relation of sleep problems to pain outcomes in people with hand osteoarthritis, and the extent to which central sensitization mediates these relationships.</div></div><div><h3>Design</h3><div>In total 299 participants from the Nor-Hand cohort study rated their sleep problems (no, slight, moderate or severe problems), hand pain intensity on a Numeric Rating Scale (NRS, range: 0–10) and Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range: 0–20), and overall bodily pain intensity (NRS). Central sensitization was evaluated by quantitative sensory testing. All pain questionnaires were repeated after 3.5 years. We explored the associations between sleep problems at baseline and pain outcomes at baseline and follow-up and fitted natural effect models to examine the extent to which measures of central sensitization mediated the effects of sleep problems on pain. All main analyses were adjusted for age, sex, education, comorbidities, and body mass index.</div></div><div><h3>Results</h3><div>Slight, moderate, and severe sleep problems were reported by 33.8 %, 26.8 % and 14.3 %, respectively. In general, individuals with severe versus without sleep problems reported relatively more intense pain at baseline and follow up (i.e., a 1.68 (95 % confidence interval 0.89–2.46) higher NRS hand pain at baseline). Associations between sleep and central sensitization were weak, with no mediating effects found. For example, the indirect effect of remote pressure pain thresholds was 0.06 (−0.27, 0.39) NRS points for hand pain among individuals reporting severe sleep problems.</div></div><div><h3>Conclusion</h3><div>Sleep problems are commonly reported and related to pain intensity in people with hand osteoarthritis, while the underlying mechanisms and temporal relationship remain unclear.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study

Osteoarthritis and cartilage open

Pub Date : 2025-02-01 DOI: 10.1016/j.ocarto.2025.100575

Khara A. James , Tuhina Neogi , David T. Felson , Patrick Corrigan , Cara L. Lewis , Irene S. Davis , Kathryn L. Bacon , James C. Torner , Cora E. Lewis , Michael C. Nevitt , Joshua J. Stefanik

Objective

Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA.

Design

Participants from the Multicenter Osteoarthritis study were included.

Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex.

Results

Among 1600 participants (60.3 % female, age 67.1 ± 7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 % (RR = 1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR = 0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR = 1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed.

Conclusion

Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation.

{"title":"Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study","authors":"Khara A. James , Tuhina Neogi , David T. Felson , Patrick Corrigan , Cara L. Lewis , Irene S. Davis , Kathryn L. Bacon , James C. Torner , Cora E. Lewis , Michael C. Nevitt , Joshua J. Stefanik","doi":"10.1016/j.ocarto.2025.100575","DOIUrl":"10.1016/j.ocarto.2025.100575","url":null,"abstract":"<div><h3>Objective</h3><div>Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA.</div></div><div><h3>Design</h3><div>Participants from the Multicenter Osteoarthritis study were included.</div><div>Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex.</div></div><div><h3>Results</h3><div>Among 1600 participants (60.3 % female, age 67.1 ± 7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 % (RR = 1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR = 0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR = 1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed.</div></div><div><h3>Conclusion</h3><div>Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100575"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review

Osteoarthritis and cartilage open

Pub Date : 2025-01-30 DOI: 10.1016/j.ocarto.2025.100577

Larissa Rix , Samuel Tushingham , Karina Wright , Martyn Snow

Background

Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.

Objectives

To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.

Results

PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.

Conclusion

Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.

{"title":"Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review","authors":"Larissa Rix , Samuel Tushingham , Karina Wright , Martyn Snow","doi":"10.1016/j.ocarto.2025.100577","DOIUrl":"10.1016/j.ocarto.2025.100577","url":null,"abstract":"<div><h3>Background</h3><div>Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities.</div></div><div><h3>Objectives</h3><div>To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change.</div></div><div><h3>Results</h3><div>PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions.</div></div><div><h3>Conclusion</h3><div>Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptoms indicative of early knee osteoarthritis after ACL reconstruction: descriptive analysis of the SHIELD cohort

Osteoarthritis and cartilage open

Pub Date : 2025-01-30 DOI: 10.1016/j.ocarto.2025.100576

Anna Cronström , May Arna Risberg , Martin Englund , Dorthe B. Strauss , Paul Neuman , Carl Johan Tiderius , Eva Ageberg

Objective

To describe the SHIELD cohort in terms of symptoms indicative of early knee osteoarthritis (OA) and to investigate associations between patient characteristics (demographics, activity/injury-related) and these symptoms at 1 (cross-sectional) and 3 years (longitudinal) post anterior cruciate ligament reconstruction (ACLR).

Method

106 participants (50 % women, mean [SD] age 25 [5] years) were included. Symptoms indicative of early knee OA were evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) subscale pain, KOOS subscale pain ≤72 (KOOSpain ≤72), and ≤85 on two out of four KOOS subscales (pain, symptoms, activity of daily living, quality of life) (modified Luyten).

Results

Mean (SD) KOOS pain scores were 83.2 (15.7) and 87.3 (12.7) at 1 and 3 years, respectively. At 1 year and 3 years post ACLR, 18/101 (18 %) and 14/86 (16 %) participants met the KOOSpain ≤72 criterion, whereas 83/101 (82 %) and 67/86 (78 %) met the modified Luyten criterion. 7/15 (47 %) (KOOSpain ≤72) and 59/70 (84 %) (modified Luyten) classified as having knee OA symptoms 1 year post ACLR were still classified as having OA symptoms after 3 years. Lower activity level at 1 year was the sole variable consistently associated with all three outcomes 3 years post ACLR.

Conclusion

The proportion of participants fulfilling existing classification criteria for symptoms indicative of early OA after ACLR is highly dependent on the criteria applied and different criteria seem to capture varying aspects of early OA symptoms. Future studies will reveal if these symptoms will persist long-term or just reflect more transient issues.

{"title":"Symptoms indicative of early knee osteoarthritis after ACL reconstruction: descriptive analysis of the SHIELD cohort","authors":"Anna Cronström , May Arna Risberg , Martin Englund , Dorthe B. Strauss , Paul Neuman , Carl Johan Tiderius , Eva Ageberg","doi":"10.1016/j.ocarto.2025.100576","DOIUrl":"10.1016/j.ocarto.2025.100576","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the SHIELD cohort in terms of symptoms indicative of early knee osteoarthritis (OA) and to investigate associations between patient characteristics (demographics, activity/injury-related) and these symptoms at 1 (cross-sectional) and 3 years (longitudinal) post anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Method</h3><div>106 participants (50 % women, mean [SD] age 25 [5] years) were included. Symptoms indicative of early knee OA were evaluated by the Knee injury and Osteoarthritis Outcome Score (KOOS) subscale pain, KOOS subscale pain ≤72 (KOOSpain ≤72), and ≤85 on two out of four KOOS subscales (pain, symptoms, activity of daily living, quality of life) (modified Luyten).</div></div><div><h3>Results</h3><div>Mean (SD) KOOS pain scores were 83.2 (15.7) and 87.3 (12.7) at 1 and 3 years, respectively. At 1 year and 3 years post ACLR, 18/101 (18 %) and 14/86 (16 %) participants met the KOOSpain ≤72 criterion, whereas 83/101 (82 %) and 67/86 (78 %) met the modified Luyten criterion. 7/15 (47 %) (KOOSpain ≤72) and 59/70 (84 %) (modified Luyten) classified as having knee OA symptoms 1 year post ACLR were still classified as having OA symptoms after 3 years. Lower activity level at 1 year was the sole variable consistently associated with all three outcomes 3 years post ACLR.</div></div><div><h3>Conclusion</h3><div>The proportion of participants fulfilling existing classification criteria for symptoms indicative of early OA after ACLR is highly dependent on the criteria applied and different criteria seem to capture varying aspects of early OA symptoms. Future studies will reveal if these symptoms will persist long-term or just reflect more transient issues.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100576"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical phenotypes and associated factors in knee osteoarthritis in an African black population

Osteoarthritis and cartilage open

Pub Date : 2025-01-29 DOI: 10.1016/j.ocarto.2025.100570

Charles Sougué , Malick Diallo , Yannick Laurent Tchenadoyo Bayala , Ismaël Ayouba Tinni , Fulgence Kaboré , Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo , Patrick Wendpouiré Hamed Dakouré , Dieu-Donné Ouedraogo

Objective

Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.

Methods

This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.

Results

A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034).

Conclusion

The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.

{"title":"Clinical phenotypes and associated factors in knee osteoarthritis in an African black population","authors":"Charles Sougué , Malick Diallo , Yannick Laurent Tchenadoyo Bayala , Ismaël Ayouba Tinni , Fulgence Kaboré , Wendlassida Joelle Stéphanie Zabsonré Tiendrebeogo , Patrick Wendpouiré Hamed Dakouré , Dieu-Donné Ouedraogo","doi":"10.1016/j.ocarto.2025.100570","DOIUrl":"10.1016/j.ocarto.2025.100570","url":null,"abstract":"<div><h3>Objective</h3><div>Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population.</div></div><div><h3>Methods</h3><div>This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors.</div></div><div><h3>Results</h3><div>A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the “osteoporotic” phenotype, 113 patients (35.2 %) exhibited the “metabolic” phenotype, 17 patients (5.3 %) exhibited the “genetic” phenotype, 24 patients (7.4 %) exhibited the “biomechanical” phenotype, and 15 patients (4.6 %) exhibited the “post-traumatic” phenotype. The “osteoporotic” phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the “post-traumatic” phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034).</div></div><div><h3>Conclusion</h3><div>The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100570"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping

Osteoarthritis and cartilage open

Pub Date : 2025-01-28 DOI: 10.1016/j.ocarto.2025.100574

Tommy Kok Annfeldt , Elisabeth Ginnerup-Nielsen , Eva Elisabeth Wæhrens , Lene Vase , Lars Erik Kristensen , Tanja Schjødt Jørgensen

Objective

This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA. It furthermore explored if other cognitive biases or heuristics were involved in the response to open-label placebo.

Method

A mixed method study in a pre-specified knee OA cohort. The influence of patient-experience, and the affect heuristic, on change in painful symptoms in response to an open-label placebo injection, were assessed using a questionnaire and multivariate linear regression. The group concept mapping method was used to characterise the expectations and hopes regarding the effect of an open-label placebo injection in non-responders and responders, defined as the lower- and upper quartile of the ΔVAS pain scores.

Results

103 participants received the questionnaire, and 60 finalised questionnaires were included in the analysis showing that the reduction in pain was associated with the patient-experience and that the affect heuristic acted as an effect modifier. Three workshops were held for non-responders (n = 13) and responders (n = 15) each generating respectively 113 and 119 statements. It was found that the two groups reported different expectations and hopes for the open label placebo injections.

Conclusions

The patient-experience influenced the response to an open label placebo injection in patients with knee OA, and this influence was moderated by the strength of the affect heuristic. Furthermore, non-responders and responders reported different hopes and expectation towards the open label placebo injection indicating the presence of the optimism bias in the responder group.

{"title":"Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping","authors":"Tommy Kok Annfeldt , Elisabeth Ginnerup-Nielsen , Eva Elisabeth Wæhrens , Lene Vase , Lars Erik Kristensen , Tanja Schjødt Jørgensen","doi":"10.1016/j.ocarto.2025.100574","DOIUrl":"10.1016/j.ocarto.2025.100574","url":null,"abstract":"<div><h3>Objective</h3><div>This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA. It furthermore explored if other cognitive biases or heuristics were involved in the response to open-label placebo.</div></div><div><h3>Method</h3><div>A mixed method study in a pre-specified knee OA cohort. The influence of patient-experience, and the affect heuristic, on change in painful symptoms in response to an open-label placebo injection, were assessed using a questionnaire and multivariate linear regression. The group concept mapping method was used to characterise the expectations and hopes regarding the effect of an open-label placebo injection in non-responders and responders, defined as the lower- and upper quartile of the ΔVAS pain scores.</div></div><div><h3>Results</h3><div>103 participants received the questionnaire, and 60 finalised questionnaires were included in the analysis showing that the reduction in pain was associated with the patient-experience and that the affect heuristic acted as an effect modifier. Three workshops were held for non-responders (<em>n</em> = 13) and responders (<em>n</em> = 15) each generating respectively 113 and 119 statements. It was found that the two groups reported different expectations and hopes for the open label placebo injections.</div></div><div><h3>Conclusions</h3><div>The patient-experience influenced the response to an open label placebo injection in patients with knee OA, and this influence was moderated by the strength of the affect heuristic. Furthermore, non-responders and responders reported different hopes and expectation towards the open label placebo injection indicating the presence of the optimism bias in the responder group.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0