Modelling the distribution of the oxygen-haemoglobin dissociation curve in vivo: An observational study

IF 1.6 4区医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI:10.1016/j.resp.2025.104400

Colin J. Crooks , Joe West , Joanne R. Morling , Mark Simmonds , Irene Juurlink , Steve Briggs , Simon Cruickshank , Susan Hammond-Pears , Dominick Shaw , Timothy R. Card , Andrew W. Fogarty

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Abstract

Few studies have explored the variability of the oxygen-haemoglobin dissociation curve in vivo.

96,428 blood gas measurements were obtained (80,376 arterial, 6959 venous) from a cohort of 7656 patients who were admitted to a large UK teaching hospital between 1 February 2020 and 31 December 2021 for a Covid-19 related admission with a positive PCR. There was consistent variation of the distribution of the oxygen-haemoglobin curve across most oxygen saturation strata with typical values at 91–92 % saturation (mean 8.1kPa, standard deviation sd 0.6 kPa or 60.8 mmHg sd 4.5 mmHg), with the exception of the highest strata of oxygen saturation of 99–100 % (mean 17.7 kPa, sd 8.1kPa or 132 mmHg sd 60.8).

The higher oxygen partial pressures at higher oxygen saturations are a concern in view of the increased mortality observed in RCTs of higher oxygen saturation targets. However, the observational study design precludes any attribution of causality.

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模拟体内氧-血红蛋白解离曲线的分布：一项观察性研究

很少有研究探索体内氧-血红蛋白解离曲线的变异性。从2020年2月1日至2021年12月31日期间入住英国一家大型教学医院的7656名患者中获得了96,428项血气测量（80,376项动脉测量，6959项静脉测量），这些患者入院时与Covid-19相关，PCR阳性。氧-血红蛋白曲线分布在大多数氧饱和度地层中具有一致的变化，典型值为91-92 %饱和度（平均8.1kPa，标准差sd 0.6 kPa或60.8 mmHg sd 4.5 mmHg），但氧饱和度最高的地层为99-100 %（平均17.7 kPa，标准差8.1kPa或132 mmHg sd 60.8）。考虑到在高氧饱和度目标的随机对照试验中观察到的死亡率增加，高氧饱和度下的高氧分压是一个值得关注的问题。然而，观察性研究的设计排除了任何因果关系的归因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.