Impact of different dosages of e-beam irradiation on mechanical strength of vitamin E-blended ultra-high-molecular-weight polyethylene and the osteolytic activities of its wear debris

IF 3 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Materialia Pub Date : 2025-01-18 DOI:10.1016/j.mtla.2025.102345
Junki Shiota , Daisuke Takahashi , Liyile Chen , Shunichi Yokota , Tomoyo Yutani , Hend Alhasan , Tsutomu Endo , Tomohiro Sugimoto , Keita Uetsuki , M Alaa Terkawi , Norimasa Iwasaki
{"title":"Impact of different dosages of e-beam irradiation on mechanical strength of vitamin E-blended ultra-high-molecular-weight polyethylene and the osteolytic activities of its wear debris","authors":"Junki Shiota ,&nbsp;Daisuke Takahashi ,&nbsp;Liyile Chen ,&nbsp;Shunichi Yokota ,&nbsp;Tomoyo Yutani ,&nbsp;Hend Alhasan ,&nbsp;Tsutomu Endo ,&nbsp;Tomohiro Sugimoto ,&nbsp;Keita Uetsuki ,&nbsp;M Alaa Terkawi ,&nbsp;Norimasa Iwasaki","doi":"10.1016/j.mtla.2025.102345","DOIUrl":null,"url":null,"abstract":"<div><div>Global medical implant manufacturing has been extensively focused on the development of materials with high mechanical strength, fatigue resistance and reduced biologically osteolytic activity in vivo. Electron beam (e-beam) irradiation has been widely used for creating a highly crosslinked vitamin E blended UHMWPE. Here, we evaluated the mechanical properties of VE-UHMWPE irradiated by e-beam with dosages of 150 and 300 kGy, and the biological responses to the material wear debris. Oxidation index values for VE-UHMWPE irradiated by 300 kGy were significantly higher than these irradiated by 150 kGy. Although VE-UHMWPE irradiated by 300 kGy exhibited significantly reduced values of the impact strength values and elongation as compared to these irradiated by 150 kG, wear productions in hip simulator test were comparable in both types of VE-UHMWPE. Furthermore, both types of VE-UHMWPE particles induced comparable inflammatory responses and osteolytic activities in vitro and in vivo. The better mechanical properties of 150-irradiated VE-UHMWPE suggest that this dosage is appropriate for crosslinking UHMWPE material of the prostheses.</div></div>","PeriodicalId":47623,"journal":{"name":"Materialia","volume":"39 ","pages":"Article 102345"},"PeriodicalIF":3.0000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materialia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589152925000122","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Global medical implant manufacturing has been extensively focused on the development of materials with high mechanical strength, fatigue resistance and reduced biologically osteolytic activity in vivo. Electron beam (e-beam) irradiation has been widely used for creating a highly crosslinked vitamin E blended UHMWPE. Here, we evaluated the mechanical properties of VE-UHMWPE irradiated by e-beam with dosages of 150 and 300 kGy, and the biological responses to the material wear debris. Oxidation index values for VE-UHMWPE irradiated by 300 kGy were significantly higher than these irradiated by 150 kGy. Although VE-UHMWPE irradiated by 300 kGy exhibited significantly reduced values of the impact strength values and elongation as compared to these irradiated by 150 kG, wear productions in hip simulator test were comparable in both types of VE-UHMWPE. Furthermore, both types of VE-UHMWPE particles induced comparable inflammatory responses and osteolytic activities in vitro and in vivo. The better mechanical properties of 150-irradiated VE-UHMWPE suggest that this dosage is appropriate for crosslinking UHMWPE material of the prostheses.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Materialia
Materialia MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
2.90%
发文量
345
审稿时长
36 days
期刊介绍: Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials. Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).
期刊最新文献
Dynamic deformation response of maraging steel 250 produced through directed energy deposition: Deformation behavior and constitutive model Effects of hyperglycemia and resveratrol on the processes of implant osseointegration and peri-implant bone remodeling: Revealed by non-linear analysis Laser-directed energy deposition as a promising dissimilar joining technique: A case study on SS316L and IN718 with CoCrFeNi-based fillers Epitaxial growth mechanism and structural characterization of spinel-type LixMn2O4 electrodes realized via pulsed laser deposition Editors for Materialia
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1