Significantly improving the degradation performance of low-alloyed Mg-1Zn-0.3Ca-1.0MgO composite in vitro and in vivo

IF 3 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Materialia Pub Date : 2024-12-28 DOI:10.1016/j.mtla.2024.102330
Chaokun Tang , Shaoyuan Lyu , Aixian Tian , Hongbin Cao , Minfang Chen
{"title":"Significantly improving the degradation performance of low-alloyed Mg-1Zn-0.3Ca-1.0MgO composite in vitro and in vivo","authors":"Chaokun Tang ,&nbsp;Shaoyuan Lyu ,&nbsp;Aixian Tian ,&nbsp;Hongbin Cao ,&nbsp;Minfang Chen","doi":"10.1016/j.mtla.2024.102330","DOIUrl":null,"url":null,"abstract":"<div><div>The <em>in vitro</em> and <em>in vivo</em> degradation behavior of a low-alloyed Mg-1Zn-0.3Ca-1.0MgO (wt.%) composite with different grain sizes were investigated to understand the effect of high-density grain boundaries (GBs) and high-volume-fraction second phases on its degradation behavior. The results indicated that the ultra-fine-grained (UFG, 0.5 μm) composite had plentiful nano-sized Ca<sub>2</sub>Mg<sub>6</sub>Zn<sub>3</sub> phase, while coarse grained (CG, 8 μm) composite possessed very few minor Ca<sub>2</sub>Mg<sub>6</sub>Zn<sub>3</sub> phases due to the high solid solubility of solute atoms in Mg matrix. The immersion test in simulated body fluids (SBF) suggested the UFG composite had a low corrosion rate of 0.68 mm/y, which was only half of the CG composite (1.39 mm/y). This improved corrosion resistance was attributed to the quick formation of a compact and stable corrosion product, resulting from the preferential corrosion of uniformly distributed GBs and second phases in the UFG matrix during the early stage (first 12 hours). This can shield the Mg matrix from further corrosion over the long term. The <em>in vivo</em> implantation results after 24 weeks also showed that the corrosion rate of UFG composite was extremely low at 0.047 mm/y, while it was 0.252 mm/y for CG composite. Such higher corrosion resistance of UFG promoted luxuriant new bone growth and a more tightly bonded interface between the bone and the sample. The matched material degradation-bone maturation rate of UFG provided a better environment for osteoblast attachment and differentiation. Furthermore, the UFG composite maintained approximately 50 % residual yield strength even after 24 weeks post-implantation, which provided excellent mechanical support during service, especially in the first three months post-implantation. These results provide insights into the composition and microstructural design, which could be a promising avenue for exploring the manufacturing of high strength and highly corrosion resistant magnesium-based materials to enhance the security as bone implant instruments.</div></div>","PeriodicalId":47623,"journal":{"name":"Materialia","volume":"39 ","pages":"Article 102330"},"PeriodicalIF":3.0000,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materialia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589152924003272","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

The in vitro and in vivo degradation behavior of a low-alloyed Mg-1Zn-0.3Ca-1.0MgO (wt.%) composite with different grain sizes were investigated to understand the effect of high-density grain boundaries (GBs) and high-volume-fraction second phases on its degradation behavior. The results indicated that the ultra-fine-grained (UFG, 0.5 μm) composite had plentiful nano-sized Ca2Mg6Zn3 phase, while coarse grained (CG, 8 μm) composite possessed very few minor Ca2Mg6Zn3 phases due to the high solid solubility of solute atoms in Mg matrix. The immersion test in simulated body fluids (SBF) suggested the UFG composite had a low corrosion rate of 0.68 mm/y, which was only half of the CG composite (1.39 mm/y). This improved corrosion resistance was attributed to the quick formation of a compact and stable corrosion product, resulting from the preferential corrosion of uniformly distributed GBs and second phases in the UFG matrix during the early stage (first 12 hours). This can shield the Mg matrix from further corrosion over the long term. The in vivo implantation results after 24 weeks also showed that the corrosion rate of UFG composite was extremely low at 0.047 mm/y, while it was 0.252 mm/y for CG composite. Such higher corrosion resistance of UFG promoted luxuriant new bone growth and a more tightly bonded interface between the bone and the sample. The matched material degradation-bone maturation rate of UFG provided a better environment for osteoblast attachment and differentiation. Furthermore, the UFG composite maintained approximately 50 % residual yield strength even after 24 weeks post-implantation, which provided excellent mechanical support during service, especially in the first three months post-implantation. These results provide insights into the composition and microstructural design, which could be a promising avenue for exploring the manufacturing of high strength and highly corrosion resistant magnesium-based materials to enhance the security as bone implant instruments.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Materialia
Materialia MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
2.90%
发文量
345
审稿时长
36 days
期刊介绍: Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials. Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).
期刊最新文献
Dynamic deformation response of maraging steel 250 produced through directed energy deposition: Deformation behavior and constitutive model Effects of hyperglycemia and resveratrol on the processes of implant osseointegration and peri-implant bone remodeling: Revealed by non-linear analysis Laser-directed energy deposition as a promising dissimilar joining technique: A case study on SS316L and IN718 with CoCrFeNi-based fillers Epitaxial growth mechanism and structural characterization of spinel-type LixMn2O4 electrodes realized via pulsed laser deposition Editors for Materialia
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1