Efficacy of extraoral photobiomodulation therapy in the management of oral mucositis in pediatric oncology patients: a preliminary study

IF 1.9 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI:10.1016/j.oooo.2024.10.104
Amanda De Farias Gabriel , Júlia Breda Soares , Luan Nathiel Santana Kovalski , Marina Curra , Mariana Bitu-Ramos Pinto , Vivian Petersen Wagner , Lauro José Gregianin , Marco Antonio Trevizani Martins , Fábio Abreu Alves , Manoela Domingues Martins
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Abstract

Objective

To compare the efficacy of intraoral (IOPBM) and extraoral photobiomodulation (EOPBM) protocols in the management of oral mucositis (OM) in pediatric patients.

Methods

This is a randomized, blinded clinical trial. Ten pediatric oncology patients were included and randomized into 2 groups: the IOPBM group (n = 5) received intraoral PBM using low-level laser, and the EOPBM group (n = 5) received extraoral PBM using defocused high-power laser. PBM therapy was administered to all patients, with a mean follow-up period of 8.8 days. Patients were evaluated daily, and OM was classified according to the World Health Organization and National Cancer Institute (NCI) scales. Additionally, oral pain, functional scores (chewing, dysphagia, fluid intake, and dysgeusia), and comfort with the procedure were assessed.

Results

Eight boys and 2 girls were included, with an average age of 8.4 years. Diagnoses included 50% acute lymphoblastic leukemia, 30% lymphomas, and 20% osteosarcoma. OM was classified by World Health Organization as grade 0 (10%), 1 (30%), 2 (50%), and 3 (10%). No patient experienced grade 4 OM. The mean duration of grade 2 OM was 2.2 days, and grade 3 was 1 day. No differences were observed between groups regarding OM grades, duration of OM, functional score, and comfort. Pain scores were similar between groups on days 3, 10, and 14. On Day 7, EOPBM exhibited a pain score of 2.2, which was higher than IOPBM (P = .018).

Conclusion

EOPBM could be considered as effective as IOPBM in the prevention and treatment of OM in pediatric oncology patients.
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口腔外光生物调节治疗小儿肿瘤患者口腔黏膜炎的疗效:初步研究
目的比较口腔内(IOPBM)与口腔外光生物调节(EOPBM)治疗小儿口腔黏膜炎(OM)的疗效。方法随机、盲法临床试验。纳入10例儿科肿瘤患者,随机分为2组:IOPBM组(n = 5)采用低水平激光进行口内PBM治疗,EOPBM组(n = 5)采用散焦高功率激光进行口外PBM治疗。所有患者均接受PBM治疗,平均随访时间为8.8天。每天对患者进行评估,并根据世界卫生组织和国家癌症研究所(NCI)的量表对OM进行分类。此外,还评估了口腔疼痛、功能评分(咀嚼、吞咽困难、液体摄入和发音困难)和手术舒适度。结果男8例,女2例,平均年龄8.4岁。诊断包括50%急性淋巴细胞白血病,30%淋巴瘤和20%骨肉瘤。世界卫生组织将OM分为0级(10%)、1级(30%)、2级(50%)和3级(10%)。没有患者出现4级OM。2级OM的平均病程为2.2 d, 3级OM的平均病程为1 d。两组之间在OM等级、OM持续时间、功能评分和舒适度方面没有观察到差异。在第3、10和14天,两组之间的疼痛评分相似。第7天,EOPBM的疼痛评分为2.2,高于IOPBM (P = .018)。结论eopbm与IOPBM在预防和治疗小儿肿瘤OM方面具有同等效果。
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来源期刊
Oral Surgery Oral Medicine Oral Pathology Oral Radiology
Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.80
自引率
6.90%
发文量
1217
审稿时长
2-4 weeks
期刊介绍: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.
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