Antimicrobial and antiviral effect of cellulose acetate nanofibres doped with pyrrolidone against methicillin-resistant Staphylococcus aureus (MRSA) and human coronavirus 229E (HCoV-229E)

IF 5.4 Q2 ENGINEERING, ENVIRONMENTAL Journal of hazardous materials advances Pub Date : 2025-02-01 DOI:10.1016/j.hazadv.2025.100598

Shahrul Nizam Md. Salleh , Mohamad Zaki Abdullah , Mohamed Shuaib Mohamed Saheed , Mohd Fazli Mohammat

{"title":"Antimicrobial and antiviral effect of cellulose acetate nanofibres doped with pyrrolidone against methicillin-resistant Staphylococcus aureus (MRSA) and human coronavirus 229E (HCoV-229E)","authors":"Shahrul Nizam Md. Salleh , Mohamad Zaki Abdullah , Mohamed Shuaib Mohamed Saheed , Mohd Fazli Mohammat","doi":"10.1016/j.hazadv.2025.100598","DOIUrl":null,"url":null,"abstract":"<div><div>The paper investigated the effectiveness of cellulose acetate (CA) nanofibres doped with a newly synthesized compound against MRSA microbe and HCoV-229E virus. MRSA microbe was responsible for antibiotic resistance diseases and HCoV-229E virus can cause mild to chronic respiratory tract infections. The pyrrolidone compound was synthesized using a one-pot sonochemistry technique and was chemically characterized followed by a toxicological assessment. Subsequently, it was dissolved in a tri-solvent solution containing cellulose acetate and electrospun to create the nanofibre membrane. The resulting membrane underwent characterization and testing against MRSA bacteria and HCoV-229E virus. The findings indicate that the nanofibre membrane, doped with the synthesized pyrrolidone compound, effectively inhibits the growth of MRSA bacteria and HCoV-229E virus.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"17 ","pages":"Article 100598"},"PeriodicalIF":5.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of hazardous materials advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772416625000105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

The paper investigated the effectiveness of cellulose acetate (CA) nanofibres doped with a newly synthesized compound against MRSA microbe and HCoV-229E virus. MRSA microbe was responsible for antibiotic resistance diseases and HCoV-229E virus can cause mild to chronic respiratory tract infections. The pyrrolidone compound was synthesized using a one-pot sonochemistry technique and was chemically characterized followed by a toxicological assessment. Subsequently, it was dissolved in a tri-solvent solution containing cellulose acetate and electrospun to create the nanofibre membrane. The resulting membrane underwent characterization and testing against MRSA bacteria and HCoV-229E virus. The findings indicate that the nanofibre membrane, doped with the synthesized pyrrolidone compound, effectively inhibits the growth of MRSA bacteria and HCoV-229E virus.

Abstract Image