Exploring the phytochemical and pharmacological insights of the plant Dolichandrone falcata

Abstract

Dolichandrone falcata Seem. belonging to Bignoniaceae family is found in Malawi, Tanzania, South Africa, Bangladesh, Pakistan, and India. In Indian states, it is found in Maharashtra, Goa, Karnataka, and Bihar. This plant's anti-diabetic, anti-inflammatory, pain-relieving (analgesic), estrogen-blocking (antiestrogenic), antimicrobial, and pain-suppressing (antinociceptive) properties, antibacterial, anti-hemorrhoidal, and immunomodulatory qualities have been traditionally utilized in India to treat a variety of ailments. This plant contains a variety of phytochemicals, including steroids, amino acids, alkaloids, flavonoids, saponins, polyphenols, terpenoids, and cardiac glycosides. This review aims to provide comprehensive and up-to-date information on the traditional applications, phytochemistry, and pharmacology of the plant in order to better understand its phytochemistry and pharmacological effects. For this review, online databases such as ScifFnder, Scopus, Springer, ScienceDirect, Wiley, Web of Science, PubMed, and Google Scholar as well as a local library for relevant articles were searched. We discovered dolichandroside A, chrysin, chrysin-7-rutinoside, rutin, pinocembrin, α-Lapachone, lapachol, verbascoside, β-sitosterol, fatty acids, etc. during the plant's phytochemical analysis. Its anti-diabetic, anti-hemorrhoidal, anti-ulcer, anti-mycobacterial, anti-hyperlipidemic, antifungal, antimicrobial, antifertility, anti-inflammatory, and antinociceptive properties have also been demonstrated. This review has not only shed light on the latest scientific advancements related to this plant but has also underscored the pressing issue of its dwindling availability. The significance of this plant, particularly for its potential health benefits, cannot be overstated. Further, the information desiminated through this review may act as a knowledge source for researchers who wish to scientifically explore this plant