Nanomaterial-based electrochemical sensors for anti-HIV drug monitoring: Innovations, challenges, and prospects

Abstract

Monitoring human immunodeficiency virus (HIV) and anti-HIV drugs is critical for optimizing treatment outcomes and preventing drug resistance. Accurate detection and quantification of anti-HIV drugs are essential to ensure appropriate dosing, enhancing patient care and therapeutic efficacy. Electrochemical biosensors have emerged as a pivotal tool in this context, offering high sensitivity, specificity, and rapid response times. Leveraging advancements in nanomaterials, these sensors provide reliable and efficient solutions for point-of-care (POC) applications in clinical and environmental settings. This review presents a comprehensive analysis of recent innovations in electrochemical sensor technologies for anti-HIV drug detection and quantification, focusing on nanomaterial-based platforms. It addresses the challenges of developing and implementing these technologies, including matrix effects, stability, and scalability. Furthermore, the review explores future directions, emphasizing the integration of sensors into POC systems and their potential to revolutionize personalized HIV treatment and pharmaceutical monitoring.