Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-12-20 DOI:10.1007/s13738-024-03151-2

Naoya Ohmori, Takamitsu Miyagi, Toshiaki Nakano, Simon Peter Bahau, Yohei Kono, Toshikazu Adachi, Satoshi Hiratsuka, Shigeru Goto, Masafumi Inomata, Takeshi Goto

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Abstract

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.

Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.

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建立了采用乙醇基结晶法和悬浮法纯化α -硫辛酸衍生物组氨酸锌钠二硫代辛酰胺的工艺

α -硫辛酸（LA）已成为多种维生素配方、抗衰老补充剂甚至宠物食品中的常见成分。它被定义为一种预防糖尿病多发性神经病变、清除自由基、螯合金属和恢复细胞内谷胱甘肽水平的治疗方法，否则细胞内谷胱甘肽水平会随着年龄的增长而下降。组氨酸锌二硫代辛酰胺钠（DHL-HisZn_Na）是一种水溶性物质，具有较强的抗氧化和抗炎性能，类似于α-硫辛酸与组氨酸结合，锌与硫原子螯合。DHL-HisZn_Na在干燥、黑暗和冷藏条件下会慢慢失去稳定性。长期储存后，净化是必不可少的。本研究首次采用乙醇结晶法和悬浮法作为DHL-HisZn_Na的纯化方法。

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.