{"title":"Reductive coupling of 2,2'-dinitrobiphenyls into benzo[c]cinnolines with NaHS.","authors":"Pingbing Yu, Zhaoyue Wen, Chun Wang, Jianlian Wu, Tie-Gen Chen, Wei Chen","doi":"10.1007/s11030-024-11087-1","DOIUrl":null,"url":null,"abstract":"<p><p>An efficient and selective method for the reduction of 2,2'-dinitrobiphenyls with NaHS to prepare benzo[c]cinnoline and benzo[c]indole N-oxide was developed. This reductive coupling protocol proceeded as quick as 20 min, and gave moderate to good yields under ambient conditions. It was straightforward and easily scalable to produce various of benzo[c]cinnoline derivatives with diverse substitution patterns.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Diversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11030-024-11087-1","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
An efficient and selective method for the reduction of 2,2'-dinitrobiphenyls with NaHS to prepare benzo[c]cinnoline and benzo[c]indole N-oxide was developed. This reductive coupling protocol proceeded as quick as 20 min, and gave moderate to good yields under ambient conditions. It was straightforward and easily scalable to produce various of benzo[c]cinnoline derivatives with diverse substitution patterns.
期刊介绍：
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;
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