Deoxycholate for Subcutaneous Fat Reduction: A Review of Current Literature and Potential New Delivery Systems.

IF 2.2 3区医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2025-02-04 DOI:10.1097/DSS.0000000000004565

Rodrigo Moreira Caetano Pinto, Guilherme Moreira Caetano Pinto, Flávio Luís Beltrame, Priscileila Colerato Ferrari

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Abstract

Background: Deoxycholate is approved for submental fat reduction due to its ability to lyse cells and reduce fat accumulation, but it is used off-label in aesthetic treatments for subcutaneous fat reduction for several other parts of the body.

Objective: Review the clinical evidence supporting using sodium deoxycholate and delivery systems for aesthetic purposes.

Materials and methods: This systematic review explores the clinical evidence for sodium deoxycholate's efficacy and safety in fat reduction, exploring the use of delivery systems to mitigate adverse effects. A comprehensive literature search across Web of Science, Scopus, and PubMed was executed to prepare this review.

Results: Clinical studies confirm that subcutaneous deoxycholate injections effectively reduce submental fat, with long-term results suggesting maintained efficacy up to 3 years post-treatment. However, adverse effects are noted, prompting research into novel delivery systems, which include sustained-release liquid crystal formulations and micro/nanoparticle-based systems, promising to reduce side effects while enhancing efficacy.

Conclusion: The findings underscore that deoxycholate is clinically well-established in efficacy and safety, with substantial evidence for treating submental fat. More extensive clinical studies are necessary to establish its safety and effectiveness in larger treatment areas and optimize treatment outcomes using different delivery systems.

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用于减少皮下脂肪的脱氧胆酸盐：现有文献综述和潜在的新给药系统

背景：脱氧胆酸盐因其溶解细胞和减少脂肪堆积的能力而被批准用于颏下脂肪减少，但它在标签外用于身体其他部位的皮下脂肪减少的美容治疗。目的：回顾临床证据支持使用脱氧胆酸钠和输送系统的美学目的。材料和方法：本系统综述探讨了脱氧胆酸钠减脂的有效性和安全性的临床证据，探索了使用给药系统来减轻不良反应。为了准备这篇综述，我们对Web of Science、Scopus和PubMed进行了全面的文献检索。结果：临床研究证实，皮下脱氧胆酸盐注射可有效减少颏下脂肪，长期结果表明，治疗后3年仍保持疗效。然而，副作用也被注意到，这促使人们研究新的给药系统，包括缓释液晶配方和微/纳米颗粒为基础的系统，有望减少副作用，同时提高疗效。结论：研究结果强调脱氧胆酸盐的有效性和安全性在临床上是公认的，有大量证据表明它可以治疗颏下脂肪。需要进行更广泛的临床研究，以确定其在更大治疗领域的安全性和有效性，并使用不同的给药系统优化治疗结果。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.