Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY Frontiers in Aging Neuroscience Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1510781

Jie Lin, Hongchen Shen, Wenjuan Yang, Guojun Zhang, Jie Sun, Wenqin Shen, Li Huang, Huajian Chen

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Abstract

Background: Obesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. Weight-adjusted waist index (WWI) is a novel measure of obesity that may offer more precise assessments of muscle and fat mass. This study aims to investigate the association between WWI and cognitive function in older Chinese men.

Methods: Data from the 2011-2018 China Longitudinal Health and Longevity Survey (CLHLS) were used in this study. WWI and cognitive function were examined in both linear and non-linear situations using Kaplan-Meier survival curves, multivariate Cox regression models, and restricted cubic spline (RCS) regression.

Results: This study included 1,392 older Chinese men aged 65 years and over for whom complete data were available. After controlling for all potential confounding variables, our analysis showed a statistically significant positive association between WWI and cognitive decline. Specifically, for every 1 cm/√kg increase in WWI, the risk of cognitive impairment increased by 17% (HR = 1.17, 95% CI: 1.02-1.35). Using 11.52 cm/√kg as the cutoff point for WWI, we found that High WWI was associated with a 44% increased risk of cognitive impairment compared with Low WWI (HR = 1.44, 95% CI: 1.07-1.96). RCS regression analysis confirmed a linear positive correlation between WWI and cognitive impairment.

Conclusion: Higher WWI is linked to worse cognitive performance in older Chinese men.

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中国老年男性体重调整腰围指数与认知障碍的关系：一项7年的纵向研究。

背景：肥胖可通过胰岛素抵抗和全身性低度炎症等机制损害中枢神经系统，损害认知功能。体重调整腰围指数（WWI）是一种新的肥胖测量方法，可以更精确地评估肌肉和脂肪质量。本研究旨在探讨第一次世界大战与中国老年男性认知功能的关系。方法：采用2011-2018年中国健康与寿命纵向调查（CLHLS）数据。使用Kaplan-Meier生存曲线、多变量Cox回归模型和限制性三次样条（RCS）回归，研究了WWI和认知功能在线性和非线性情况下的关系。结果：这项研究包括1392名年龄在65岁 及以上的中国老年男性，他们的数据完整。在控制了所有潜在的混杂变量后，我们的分析显示第一次世界大战与认知能力下降之间存在统计学上显著的正相关。具体而言，WWI每增加1 cm/√kg，认知功能障碍的风险增加17% （HR = 1.17,95% CI: 1.02-1.35）。使用11.52 cm/√kg作为WWI的截止点，我们发现与低WWI相比，高WWI与认知障碍风险增加44%相关（HR = 1.44,95% CI: 1.07-1.96）。RCS回归分析证实第一次世界大战与认知功能障碍呈线性正相关。结论：较高的WWI与老年中国男性较差的认知表现有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.