The Role of Muscle Architecture as a Determinant of Functional Performance in Women With Knee Osteoarthritis.

IF 1.8 Q3 REHABILITATION Physiotherapy Research International Pub Date : 2025-04-01 DOI:10.1002/pri.70030

Nazli Cigercioglu, Zilan Bazancir-Apaydin, Ezgi Unuvar-Yuksel, Hakan Apaydin, Gul Baltaci, Hande Guney-Deniz

{"title":"The Role of Muscle Architecture as a Determinant of Functional Performance in Women With Knee Osteoarthritis.","authors":"Nazli Cigercioglu, Zilan Bazancir-Apaydin, Ezgi Unuvar-Yuksel, Hakan Apaydin, Gul Baltaci, Hande Guney-Deniz","doi":"10.1002/pri.70030","DOIUrl":null,"url":null,"abstract":"Background and purpose: Knee osteoarthritis (KOA) is associated with early muscular alterations and muscle weakness, which contribute to disease progression. However, limited knowledge exists regarding the potential exacerbation of lower extremity muscle architecture and its impact on functional performance. This study aimed to investigate the relationship between knee extensor and ankle plantar flexor muscle architecture, femoral cartilage thickness, age, body mass index (BMI), pain severity, and functional performance in middle-aged women with KOA.Methods: A total of 87 patients diagnosed with KOA (mean age = 51.48 ± 4.89 years, mean BMI = 27.96 ± 4.66 kg/m2) were included in the study. Ultrasonography was used to assess muscle thickness, adipose tissue thickness, pennation angle, and the muscle/adipose tissue thickness ratio (MATR) of the Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), and Medial Gastrocnemius (MG) muscles. Physical performance was evaluated through the stair-climbing test and the 10-time sit to stand test. Pearson's correlation test and multiple linear regression analysis were used.Results: The pennation angle of the VL and pain level predicted sit to stand test results; the pennation angle of RF, age, BMI and pain level predicted stair-climbing test results (p < 0.001). Femoral cartilage thickness at the medial condyle, intercondylar area, and lateral condyle correlated with performance in both tests (p < 0.001). Additionally, age, BMI, pain intensity, muscle thickness, pennation angle and MATR of RF, VL, and VM correlated with both functional tests (p < 0.05).Discussion: Muscle architecture alterations correlated with functional test results in patients with KOA. Understanding the influence of muscle architecture on functional parameters can facilitate the development of effective rehabilitation strategies to preserve and optimize patient function before it becomes compromised.Trial registration: Enrolled in clinical trials and awaiting approval.","PeriodicalId":47243,"journal":{"name":"Physiotherapy Research International","volume":"30 2","pages":"e70030"},"PeriodicalIF":1.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiotherapy Research International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/pri.70030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"REHABILITATION","Score":null,"Total":0}

引用次数: 0

Abstract

Background and purpose: Knee osteoarthritis (KOA) is associated with early muscular alterations and muscle weakness, which contribute to disease progression. However, limited knowledge exists regarding the potential exacerbation of lower extremity muscle architecture and its impact on functional performance. This study aimed to investigate the relationship between knee extensor and ankle plantar flexor muscle architecture, femoral cartilage thickness, age, body mass index (BMI), pain severity, and functional performance in middle-aged women with KOA.

Methods: A total of 87 patients diagnosed with KOA (mean age = 51.48 ± 4.89 years, mean BMI = 27.96 ± 4.66 kg/m²) were included in the study. Ultrasonography was used to assess muscle thickness, adipose tissue thickness, pennation angle, and the muscle/adipose tissue thickness ratio (MATR) of the Rectus Femoris (RF), Vastus Medialis (VM), Vastus Lateralis (VL), and Medial Gastrocnemius (MG) muscles. Physical performance was evaluated through the stair-climbing test and the 10-time sit to stand test. Pearson's correlation test and multiple linear regression analysis were used.

Results: The pennation angle of the VL and pain level predicted sit to stand test results; the pennation angle of RF, age, BMI and pain level predicted stair-climbing test results (p < 0.001). Femoral cartilage thickness at the medial condyle, intercondylar area, and lateral condyle correlated with performance in both tests (p < 0.001). Additionally, age, BMI, pain intensity, muscle thickness, pennation angle and MATR of RF, VL, and VM correlated with both functional tests (p < 0.05).

Discussion: Muscle architecture alterations correlated with functional test results in patients with KOA. Understanding the influence of muscle architecture on functional parameters can facilitate the development of effective rehabilitation strategies to preserve and optimize patient function before it becomes compromised.

Trial registration: Enrolled in clinical trials and awaiting approval.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肌肉结构对女性膝关节骨性关节炎患者功能表现的决定作用

背景和目的：膝骨关节炎（KOA）与早期肌肉改变和肌肉无力有关，这有助于疾病进展。然而，关于下肢肌肉结构的潜在恶化及其对功能表现的影响的知识有限。本研究旨在探讨中年KOA女性膝关节伸肌和足底屈肌结构、股骨软骨厚度、年龄、体重指数（BMI）、疼痛严重程度和功能表现之间的关系。方法：共纳入87例确诊为KOA的患者，平均年龄为51.48±4.89岁，平均BMI为27.96±4.66 kg/m2。超声检查评估股直肌（RF）、股内侧肌（VM）、股外侧肌（VL）和腓肠肌内侧肌（MG）的肌肉厚度、脂肪组织厚度、穿刺角度和肌肉/脂肪组织厚度比（MATR）。通过爬楼梯测试和10次坐立测试来评估身体性能。采用Pearson相关检验和多元线性回归分析。结果：VL的笔触角度和疼痛程度预测坐立测试结果；RF的笔角、年龄、BMI和疼痛程度预测爬楼梯测试结果(p)。讨论：KOA患者肌肉结构改变与功能测试结果相关。了解肌肉结构对功能参数的影响有助于制定有效的康复策略，在患者功能受损之前保护和优化患者功能。试验注册：参加临床试验，等待批准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Physiotherapy Research International REHABILITATION-

CiteScore

3.30

自引率

5.90%

发文量

期刊介绍： Physiotherapy Research International is an international peer reviewed journal dedicated to the exchange of knowledge that is directly relevant to specialist areas of physiotherapy theory, practice, and research. Our aim is to promote a high level of scholarship and build on the current evidence base to inform the advancement of the physiotherapy profession. We publish original research on a wide range of topics e.g. Primary research testing new physiotherapy treatments; methodological research; measurement and outcome research and qualitative research of interest to researchers, clinicians and educators. Further, we aim to publish high quality papers that represent the range of cultures and settings where physiotherapy services are delivered. We attract a wide readership from physiotherapists and others working in diverse clinical and academic settings. We aim to promote an international debate amongst the profession about current best evidence based practice. Papers are directed primarily towards the physiotherapy profession, but can be relevant to a wide range of professional groups. The growth of interdisciplinary research is also key to our aims and scope, and we encourage relevant submissions from other professional groups. The journal actively encourages submissions which utilise a breadth of different methodologies and research designs to facilitate addressing key questions related to the physiotherapy practice. PRI seeks to encourage good quality topical debates on a range of relevant issues and promote critical reflection on decision making and implementation of physiotherapy interventions.