Selective Adsorption to Pathogenic Bacteria Augments Antibacterial Activity via Adjusting the Physicochemical Property of Nanoparticles

IF 18.5 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Functional Materials Pub Date : 2025-02-06 DOI:10.1002/adfm.202416594
Zhi‐Hao Wang, Chaoran Zhu, Fengqin Zhao, Xiufang Shi, Junjie Liu, Jinjin Shi
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Abstract

Oral antibiotics are the primary method used to treat bacterial infections in clinical practice. However, the non‐selectivity of antibiotics reduces the efficacy of treatment while also tending to damage normal flora and cause dysbiosis. Obviously, it is crucial to enhance the selectivity of antibiotics against bacteria. It is possible to modulate the physicochemical properties of orally administered nanosystems to achieve selective adsorption to bacteria, thereby achieving improving bactericidal effects. A series of nanoparticles are examined bacterial adhesion characteristics focusing on five aspects: particle size, shape, charge, surface hydrophilicity, and surface modification. Selective adsorption of nanoparticles is investigated pathogenic bacteria (S. aureus as an example), normal bacteria (E. coli as an example), and probiotic bacteria (E. faecium as an example). The results show that ≈50 nm chitosan‐modified spherical Poly(lactide‐co‐glycolide) (PLGA) nanoparticles exhibit a stronger adsorption capacity for pathogenic bacteria (Staphylococcus aureus). After loading with amoxicillin, the antibacterial nanoparticles are able to destroy pathogenic bacteria without disrupting the normal intestinal bacterial flora and reducing the typical side effects of ecological disruption caused by broad‐spectrum antibiotics. Thus, this work presents a convenient and versatile strategy for targeting bacteria to enhance the antibacterial efficacy of current antibiotics.

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来源期刊
Advanced Functional Materials
Advanced Functional Materials 工程技术-材料科学:综合
CiteScore
29.50
自引率
4.20%
发文量
2086
审稿时长
2.1 months
期刊介绍: Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.
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