Enrico Michele Salamone , Matteo Carpi , Giuseppe Noce , Claudio Del Percio , Susanna Lopez , Roberta Lizio , Dharmendra Jakhar , Ali Eldellaa , Veronica Henao Isaza , Burcu Bölükbaş , Andrea Soricelli , Marco Salvatore , Bahar Güntekin , Görsev Yener , Federico Massa , Dario Arnaldi , Francesco Famà , Matteo Pardini , Raffaele Ferri , Michele Salerni , Claudio Babiloni
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Abstract
Objectives
Alzheimer’s disease patients with mild cognitive impairment (ADMCI) show abnormal resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms (8–12 Hz) and may suffer from daytime sleepiness. Our exploratory study tested the hypothesis that they may present characteristic EEG rhythms from quiet wakefulness to light sleep during diurnal recordings.
Methods
Datasets of 34 ADMCI and 22 matched healthy elderly (Nold) subjects were obtained from international archives. EEG recordings lasted approximately 30 min. Transitions of EEG activity from quiet wakefulness (alpha-dominant) to light sleep (theta-dominant ripples) were scored according to Hori’s vigilance stages. Cortical source activities were computed using the eLORETA software.
Results
ADMCI (t-ADMCI, N = 18) over Nold (t-Nold, N = 11) participants were characterized by greater frontal EEG delta source activities and a lesser reduction (reactivity) in the posterior alpha source activities from quiet wakefulness to ripples. Notably, EEG delta source activities during quiet wakefulness were also greater in the ADMCI group transitioning to light sleep as compared to patients without said vigilance reduction.
Conclusions
These results suggest that ADMCI patients with a greater susceptibility to daytime sleepiness may show characteristic EEG delta and alpha rhythms in the transition from quiet vigilance to daytime sleep.
Significance
Our study showed a derangement of EEG rhythms during the transition to sleep possibly specific to AD.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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