Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer’s disease patients with mild cognitive impairment

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI:10.1016/j.clinph.2025.01.012

Enrico Michele Salamone , Matteo Carpi , Giuseppe Noce , Claudio Del Percio , Susanna Lopez , Roberta Lizio , Dharmendra Jakhar , Ali Eldellaa , Veronica Henao Isaza , Burcu Bölükbaş , Andrea Soricelli , Marco Salvatore , Bahar Güntekin , Görsev Yener , Federico Massa , Dario Arnaldi , Francesco Famà , Matteo Pardini , Raffaele Ferri , Michele Salerni , Claudio Babiloni

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Abstract

Objectives

Alzheimer’s disease patients with mild cognitive impairment (ADMCI) show abnormal resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms (8–12 Hz) and may suffer from daytime sleepiness. Our exploratory study tested the hypothesis that they may present characteristic EEG rhythms from quiet wakefulness to light sleep during diurnal recordings.

Methods

Datasets of 34 ADMCI and 22 matched healthy elderly (Nold) subjects were obtained from international archives. EEG recordings lasted approximately 30 min. Transitions of EEG activity from quiet wakefulness (alpha-dominant) to light sleep (theta-dominant ripples) were scored according to Hori’s vigilance stages. Cortical source activities were computed using the eLORETA software.

Results

ADMCI (t-ADMCI, N = 18) over Nold (t-Nold, N = 11) participants were characterized by greater frontal EEG delta source activities and a lesser reduction (reactivity) in the posterior alpha source activities from quiet wakefulness to ripples. Notably, EEG delta source activities during quiet wakefulness were also greater in the ADMCI group transitioning to light sleep as compared to patients without said vigilance reduction.

Conclusions

These results suggest that ADMCI patients with a greater susceptibility to daytime sleepiness may show characteristic EEG delta and alpha rhythms in the transition from quiet vigilance to daytime sleep.

Significance

Our study showed a derangement of EEG rhythms during the transition to sleep possibly specific to AD.

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伴有轻度认知障碍的阿尔茨海默病患者从安静清醒到轻度睡眠的异常脑电图节律

目的阿尔茨海默病合并轻度认知障碍（ADMCI）患者静息状态闭眼脑电图(rsEEG) α节律异常（8-12 Hz），并可能出现白天嗜睡。我们的探索性研究验证了这样一种假设，即在白天的记录中，他们可能呈现出从安静清醒到轻度睡眠的特征脑电图节律。方法从国际档案中获取34例ADMCI和22例匹配的健康老年人（Nold）的数据集。脑电图记录持续约30分钟。脑电图活动从安静清醒（α -优势）到轻度睡眠（θ -优势波纹）的转变根据Hori的警戒阶段进行评分。使用eLORETA软件计算皮质源活动。结果admci组（t-ADMCI, N = 18）高于Nold组（t-Nold, N = 11）的被试表现为额叶δ源活动增强，后叶α源活动反应性减弱。值得注意的是，与没有警惕性降低的患者相比，ADMCI组在过渡到浅睡眠的安静清醒期间的EEG δ源活动也更大。结论ADMCI患者白天嗜睡易感性较高，在从安静警觉到白天睡眠的转变过程中可能表现出特征性的EEG δ和α节律。我们的研究表明，在向睡眠过渡期间，脑电图节律紊乱可能是AD特有的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.