Association of First-Trimester Combined Inflammatory Markers (NLR, SII, SIRI, and AISI) With Poor Obstetric Outcomes in Pregnancies With Ulcerative Colitis

IF 2.5 3区医学 Q3 IMMUNOLOGY American Journal of Reproductive Immunology Pub Date : 2025-02-06 DOI:10.1111/aji.70055

Osman Onur Ozkavak, Atakan Tanacan, Hakki Serbetci, Esra Karatas, Murat Haksever, Ezgi Basaran, Melike Busra Atar, Dilek Sahin

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Abstract

Aim

To compare the first-trimester combined inflammatory markers between pregnant women diagnosed with ulcerative colitis (UC) and healthy pregnant women. Furthermore, to investigate the predictive value of these markers for adverse obstetric outcomes in pregnant women affected by UC.

Methods

In this retrospective study, data were collected from pregnant women with UC who gave birth at our hospital between January 2021 and May 2024 and from a control group of healthy pregnant women. A comparison was made between the two groups in terms of their demographic characteristics, neonatal outcomes, and the values of the first-trimester neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), and aggregated index of systemic inflammation (AISI). Furthermore, the relationship between these combined inflammatory markers and adverse obstetric outcomes in pregnant women with UC was investigated.

Results

No notable discrepancy was observed between the UC group and the control group with respect to SIRI and AISI. The first-trimester NLR and SII values were observed to be higher in the UC group in comparison to the control group. The data indicated that pregnant women with UC who experienced poor obstetric outcomes exhibited elevated levels of NLR, SII, SIRI, and AISI during the first trimester. In the ROC analysis, the predictive capacity of all four parameters for poor obstetric outcomes in UC patients was statistically significant.

Conclusion

There is an association between elevated combined inflammatory markers in the first trimester and poor obstetric outcomes in pregnant women with UC.

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.