Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy.

IF 2.7 3区医学 Q3 NEUROSCIENCES Frontiers in Human Neuroscience Pub Date : 2025-01-22 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1517565

Zhisen Li, Xiaoxia Hou, Yanli Lu, Huimin Zhao, Meixia Wang, Qian Gui, Guanhui Wu, Qinrong Xu, Xiaofeng Dong, Qingzhang Cheng, Xiaowen Xu, Hongxuan Feng

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Abstract

Objective: The diagnosis of patients with non-lesional epilepsy (NLE) is relatively challenging because of the absence of a clear focus on imaging, and the underlying pathological mechanism remains unclear. The neuronal activity and functional connectivity of NLE patients are significantly abnormal, and the neuronal activity of epilepsy patients is closely related to cerebral blood flow (CBF). Neurovascular coupling (NVC) offers insights into the relationship between neuronal activity and CBF. Hence, we intend to explore the alterations of NVC in NLE patients and their influences on cognitive function.

Methods: Clinical data of 24 patients with NLE (15 female; age range 19-40 years; median age 30.5 years) and 39 healthy controls (27 female; age range 19-40 years; median age 30 years) were collected, and resting-state functional magnetic resonance imaging (rs-fMRI) and 3D arterial spin labeling (ASL) were performed. The imaging indexes of amplitude of low-frequency fluctuation (ALFF) and CBF were calculated, respectively, by post-processing analysis. The differences in CBF, ALFF and CBF/ALFF ratio between the two groups were analyzed, along with correlation with clinical data of NLE patients.

Results: Compared with the healthy controls, the CBF of the right parahippocampal gyrus was significantly decreased, and the CBF/ALFF ratio of the right inferior parietal, but supramarginal and angular gyri was significantly increased in NLE patients (p < 0.001). Moreover, the CBF/ALFF ratio was positively correlated with epilepsy depression score (r = 0.546, p = 0.006).

Conclusion: NLE patients showed abnormal local NVC, which was associated with the severity of depression. The combined application of rs-fMRI and ASL can comprehensively evaluate the neuronal activity and cerebral blood perfusion in patients with NLE. The abnormal NVC is of great significance for us to explore the central mechanism of the occurrence and development of NLE.

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非病变性癫痫患者神经血管耦合的功能MRI研究。

目的：非病变性癫痫（NLE）患者的诊断相对具有挑战性，因为缺乏明确的影像学重点，其潜在的病理机制尚不清楚。NLE患者的神经元活动和功能连通性明显异常，癫痫患者的神经元活动与脑血流量（CBF）密切相关。神经血管耦合（NVC）提供了神经元活动和脑血流之间关系的见解。因此，我们打算探讨NVC在NLE患者中的改变及其对认知功能的影响。方法：收集24例NLE患者的临床资料(女性15例；年龄范围19-40岁 岁；中位年龄30.5 岁)和39名健康对照者(27名女性；年龄范围19-40岁 岁；中位年龄30 岁)，进行静息状态功能磁共振成像（rs-fMRI）和3D动脉自旋标记（ASL）。通过后处理分析，分别计算出低频波动幅度（ALFF）和CBF的成像指标。分析两组间CBF、ALFF及CBF/ALFF比值的差异，并与NLE患者临床资料的相关性。结果：与健康对照组相比，NLE患者右侧海马旁回CBF显著降低，右侧顶叶下回、边缘上回和角回CBF/ALFF比值显著升高（p r = 0.546,p = 0.006）。结论：NLE患者出现局部NVC异常，且与抑郁症严重程度有关。rs-fMRI与ASL联合应用可以综合评价NLE患者的神经元活动和脑血流灌注情况。NVC异常对探讨NLE发生发展的核心机制具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.