Association of Depression with Age at Natural Menopause: A Cross-Sectional Analysis with NHANES Data.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Women's Health Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S504748

Shuaiqi An, Shiyan Ren, Jiawen Ma, Yizhou Zhang

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Abstract

Purpose: To evaluate the association between depression and age of natural menopause in American women.

Patients and methods: This cross-sectional study utilized eight cycles of the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2023. We assessed depression using the Patient Health Questionnaire-9 (PHQ-9). We obtained ANM information from the Reproductive Health questionnaire. We screened menopausal women between the ages of 40 and 70 years, excluding those with surgical menopause. We used multivariable logistic regression models to investigate the association between depression and ANM. Additionally, we conducted subgroup analyses and interaction tests.

Results: A total of 4732 women were included, and the mean age of natural menopause was 47.9 ± 6.8 years. Of these, 1123 (23.7%) were classified as early menopause, 2971 (62.8%) as normal menopause, and 638 (13.5%) as late menopause. Preliminary analysis showed a positive association between PHQ-9 score and the risk of early menopause (OR = 1.11, 95% CI = 1.06-1.16). After full adjustment in multivariate logistic regression, it was estimated that each one-unit increase in the PHQ-9 score was associated with a 7% increased risk of early menopause (OR = 1.07, 95% CI = 1.02-1.12). After classifying depression into three grades: no, mild, and severe, it was found that, compared with American women without depression, the risk of early menopause increased significantly. American women with major depression had an increased risk of early menopause (OR = 2.49, 95% CI = 1.10-5.63). In College or above (OR = 1.10, 95% CI = 1.02-1.19), PIR≤1 (OR = 1.10, 95% CI = 1.04-1.16), Current smoker (OR = 1.12, 95% CI = 1.00-1.24), the positive association between depression and early menopause was more significant.

Conclusion: In this cross-sectional study, the severity of depression in American women was positively correlated with the risk of early menopause. This suggests that women should pay more attention to their mental health and actively manage depression. For women with depression, early intervention and treatment may help improve their reproductive health and delay menopause.

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抑郁症与自然绝经年龄的关系：NHANES数据的横断面分析。

目的：评价美国女性抑郁与自然绝经年龄的关系。患者和方法：本横断面研究利用了2005年至2023年进行的8个周期的国家健康和营养检查调查（NHANES）。我们使用患者健康问卷-9 （PHQ-9）评估抑郁症。我们从生殖健康问卷中获得了ANM信息。我们筛选了年龄在40到70岁之间的绝经妇女，不包括那些手术绝经的妇女。我们使用多变量逻辑回归模型来研究抑郁症与ANM之间的关系。此外，我们还进行了亚组分析和相互作用测试。结果：共纳入4732名女性，平均自然绝经年龄为47.9±6.8岁。其中，早期绝经1123例（23.7%），正常绝经2971例（62.8%），晚期绝经638例（13.5%）。初步分析显示PHQ-9评分与早期绝经风险呈正相关（OR = 1.11, 95% CI = 1.06-1.16）。在多变量logistic回归完全调整后，估计PHQ-9评分每增加1个单位与提前绝经风险增加7%相关（OR = 1.07, 95% CI = 1.02-1.12）。将抑郁症分为无、轻度、重度三个等级后发现，与没有抑郁症的美国女性相比，提前绝经的风险明显增加。患有重度抑郁症的美国女性提前绝经的风险增加（OR = 2.49, 95% CI = 1.10-5.63）。大专及以上（or = 1.10, 95% CI = 1.02-1.19）、PIR≤1 （or = 1.10, 95% CI = 1.04-1.16）、当前吸烟者（or = 1.12, 95% CI = 1.00-1.24）中，抑郁与提前绝经的正相关更为显著。结论：在本横断面研究中，美国女性抑郁症的严重程度与提前绝经的风险呈正相关。这表明女性应该更加关注自己的心理健康，积极应对抑郁症。对于患有抑郁症的妇女，早期干预和治疗可能有助于改善她们的生殖健康和推迟更年期。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.