{"title":"Protective effect of <i>Urtica urens</i> L. against nephrotoxicity induced by imidacloprid in rats.","authors":"Massara Mzid, Khansa Chaabouni, Fatma Ayedi, Zouheir Sahnoun, Ahmed Hakim, Tarek Rebai","doi":"10.1080/14786419.2024.2447045","DOIUrl":null,"url":null,"abstract":"<p><p>Imidacloprid (IMI) has been known to cause nephrotoxicity. Some reports claim that <i>Urtica urens</i> L. (<i>U. urens</i>) can reduce toxicity. The present study was undertaken to evaluate the protective effect of <i>U. urens</i> against this toxicity. Rats were divided into control group, three groups treated with IMI at 50, 200, or 300 mg/kg/day and three groups injected with IMI (50, 200, or 300 mg/kg/day) + 100 mg/kg/day of <i>U. urens</i>, for 60 days. Urine and blood samples were collected for dosage of biochemical levels. Kidneys were removed for oxidative stress and histological examination. IMI caused acute renal injury and increased the levels of biochemical and tissue MDA. It also decreased the levels of antioxidant enzyme activities. <i>Urtica urens</i> injection improved the histological and all biochemical parameters. IMI induced an acute renal injury accompanied with disturbance of oxidant status <i>U. urens</i> injection provided a significant protection thanks to antioxidant properties.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.6000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2447045","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Imidacloprid (IMI) has been known to cause nephrotoxicity. Some reports claim that Urtica urens L. (U. urens) can reduce toxicity. The present study was undertaken to evaluate the protective effect of U. urens against this toxicity. Rats were divided into control group, three groups treated with IMI at 50, 200, or 300 mg/kg/day and three groups injected with IMI (50, 200, or 300 mg/kg/day) + 100 mg/kg/day of U. urens, for 60 days. Urine and blood samples were collected for dosage of biochemical levels. Kidneys were removed for oxidative stress and histological examination. IMI caused acute renal injury and increased the levels of biochemical and tissue MDA. It also decreased the levels of antioxidant enzyme activities. Urtica urens injection improved the histological and all biochemical parameters. IMI induced an acute renal injury accompanied with disturbance of oxidant status U. urens injection provided a significant protection thanks to antioxidant properties.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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