{"title":"PcloC-Mediated Phase Separation in Short-Distance Vesicle Transport.","authors":"Huyong Yan, Yixuan Deng","doi":"10.1111/tra.12959","DOIUrl":null,"url":null,"abstract":"<p><p>Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component system into distinct phases with varying compositions and structures. The latest study has found that protein aggregates formed through phase separation can effectively realize short-distance transport of vesicles. PcloC responds to calcium through C2A domain-mediated calcium sensing, thereby extracting synaptic vesicles from the reserve pool where synaptic proteins aggregate into the surface of the active zone protein condensate. Therefore, PcloC-mediated phase separation may provide a new perspective to understanding short-distance directional transport within cells.</p>","PeriodicalId":23207,"journal":{"name":"Traffic","volume":"25 11-12","pages":"e12959"},"PeriodicalIF":3.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Traffic","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1111/tra.12959","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component system into distinct phases with varying compositions and structures. The latest study has found that protein aggregates formed through phase separation can effectively realize short-distance transport of vesicles. PcloC responds to calcium through C2A domain-mediated calcium sensing, thereby extracting synaptic vesicles from the reserve pool where synaptic proteins aggregate into the surface of the active zone protein condensate. Therefore, PcloC-mediated phase separation may provide a new perspective to understanding short-distance directional transport within cells.
期刊介绍：
Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement.
All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision.
Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.
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