Effects of Steroidal Compounds on Viruses.

IF 1.5 4区 医学 Q4 IMMUNOLOGY Viral immunology Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI:10.1089/vim.2024.0011
Li Zhao, Guanghuan Shen, Jianghan Luo, Yingyu Zhang, Ying Yao, Linlin Cui, Bo Yang
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引用次数: 0

Abstract

Viral infections are ubiquitous, and their prevention and treatment have become a great challenge. Steroids have different biological activities, including antiviral activity, which is related to steroid structural diversity. With the intensive study of steroids, it has been found that steroids can interfere with almost any step of the viral life cycle to exert antiviral activity. In this article, we review the antiviral activity and mechanism of action of steroids and their derivatives against a range of human viruses and conclude that natural steroids and their derivatives are very promising antiviral drug candidates that deserve further study to elucidate their pharmacological potential.

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甾体化合物对病毒的作用。
病毒感染无处不在,其预防和治疗已成为一个巨大的挑战。类固醇具有不同的生物活性,包括抗病毒活性,这与类固醇结构的多样性有关。随着对类固醇的深入研究,已经发现类固醇可以干扰病毒生命周期的几乎任何步骤来发挥抗病毒活性。本文综述了类固醇及其衍生物对多种人类病毒的抗病毒活性和作用机制,认为天然类固醇及其衍生物是非常有前途的抗病毒候选药物,值得进一步研究以阐明其药理潜力。
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来源期刊
Viral immunology
Viral immunology 医学-病毒学
CiteScore
3.60
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.
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