{"title":"Mitochondrial heterogeneity: subpopulations with distinct metabolic activities","authors":"Fabian den Brave, Swadha Mishra, Thomas Becker","doi":"10.1038/s41392-025-02130-0","DOIUrl":null,"url":null,"abstract":"<p>In a recent study published in <i>Nature</i>, Ryu et al.<sup>1</sup> demonstrate the presence of metabolically distinct mitochondrial subpopulations within one cell. One mitochondrial subpopulation contains the F<sub>1</sub>F<sub>O</sub>-ATP synthase for oxidative phosphorylation (OXPHOS), while a second population performs reductive biosynthesis of proline and ornithine. The separation of mitochondria into two functionally distinct pools is reversible and depends on their fusion and fission.</p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":"40 1","pages":""},"PeriodicalIF":40.8000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-025-02130-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In a recent study published in Nature, Ryu et al.1 demonstrate the presence of metabolically distinct mitochondrial subpopulations within one cell. One mitochondrial subpopulation contains the F1FO-ATP synthase for oxidative phosphorylation (OXPHOS), while a second population performs reductive biosynthesis of proline and ornithine. The separation of mitochondria into two functionally distinct pools is reversible and depends on their fusion and fission.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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