{"title":"Revolutionizing cervical cancer diagnostics: A shift from traditional techniques to biosensors","authors":"Ubaid Mushtaq Naikoo , Roberto Pilloton , Humaira Farooqi , Jagriti Narang","doi":"10.1016/j.biosx.2025.100587","DOIUrl":null,"url":null,"abstract":"<div><div>Cervical cancer is the most important contributor to ailment and death among females universally, highlighting the urgent need for effective diagnostic tools. Traditional diagnostic techniques, such as Pap smears and HPV testing, though effective, suffer from limitations including invasiveness, variable sensitivity, and dependence on clinical infrastructure. This review explores the transformative potential of biosensors as a non-invasive, cost-effective, and sensitive alternative for cervical cancer diagnostics. Comprehensive analysis of current biosensor technologies, emphasizing their mechanisms, advantages, and potential to overcome the drawbacks of conventional methods. Furthermore, the review discusses recent advancements in biosensor design, including integrating nanomaterials and point-of-care systems, which enhance their diagnostic accuracy and accessibility. Key challenges in the clinical translation of biosensors are also addressed, along with potential solutions and future research directions. By highlighting the shift from traditional techniques to biosensors, this review underscores the promise of these innovative tools in improving early detection and patient outcomes in cervical cancer care.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100587"},"PeriodicalIF":10.6100,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors and Bioelectronics: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590137025000147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Cervical cancer is the most important contributor to ailment and death among females universally, highlighting the urgent need for effective diagnostic tools. Traditional diagnostic techniques, such as Pap smears and HPV testing, though effective, suffer from limitations including invasiveness, variable sensitivity, and dependence on clinical infrastructure. This review explores the transformative potential of biosensors as a non-invasive, cost-effective, and sensitive alternative for cervical cancer diagnostics. Comprehensive analysis of current biosensor technologies, emphasizing their mechanisms, advantages, and potential to overcome the drawbacks of conventional methods. Furthermore, the review discusses recent advancements in biosensor design, including integrating nanomaterials and point-of-care systems, which enhance their diagnostic accuracy and accessibility. Key challenges in the clinical translation of biosensors are also addressed, along with potential solutions and future research directions. By highlighting the shift from traditional techniques to biosensors, this review underscores the promise of these innovative tools in improving early detection and patient outcomes in cervical cancer care.
期刊介绍:
Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.