Rôle de l’axe microbiote-intestin-cerveau dans la dérégulation du comportement alimentaire au cours de l’obésité et de l’hyperphagie boulimique : les mécanismes

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Nutrition Clinique et Metabolisme Pub Date : 2023-12-01 DOI:10.1016/S0985-0562(24)00007-4

Marie Galmiche , Pierre Déchelotte

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引用次数: 0

Abstract

Eating disorders (ED), particularly compulsive ED such as binge eating disorder (BED), play an important role in the pathophysiology of obesity. Recent data have highlighted the involvement of the microbiotagut-brain axis in the regulation of eating behavior; its deregulation could therefore contribute to the onset of obesity via the development or perpetuation of ED, in particular BED. This review highlights the various peripheral and central pathophysiological mechanisms linking intestinal dysbiosis and the disruption of eating behavior leading to obesity and BED. The main peripheral regulatory signals involved are peptides associated with food intake (ghrelin, GLP-1), short-chain fatty acids and bacterial components. The brain integration of peripheral and central signals modulating food intake, involving at homeostatic (arcuate nucleus of the hypothalamus) and hedonic (reward system) levels, will be described during BED and obesity. This better understanding of the role of the microbiota-gut-brain axis in the control of eating behavior in relation to the pathophysiology of obesity opens up prospects for innovative therapeutic strategies targeting gut microbiota reshaping.

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.