Unraveling the role of lncRNA in Endometriosis-Associated immune system Dysregulation: Exploring the intricate immunological changes and disrupted signaling pathways
{"title":"Unraveling the role of lncRNA in Endometriosis-Associated immune system Dysregulation: Exploring the intricate immunological changes and disrupted signaling pathways","authors":"Enwa Felix Oghenemaro , Ahmed Hjazi , Farag M.A. Altalbawy , Ashishkumar Kyada , Deepak Nathiya , Parjinder Kaur , Subasini Uthirapathy , Muthena Kariem , M.Ravi Kumar , Israa Habeeb Naser","doi":"10.1016/j.humimm.2025.111248","DOIUrl":null,"url":null,"abstract":"<div><div>A chronic illness known as endometriosis impacts women who are of reproductive maturity. It may be a factor in fertility problems, breast or ovarian cancer, asthma, cardiovascular illness, or pelvic pain. Studies have indicated that malfunctioning of the immune system is one of the prerequisites for the occurrence of endometrial diseases. Immune cells such as neutrophils and macrophages seem to be involved in the angiogenesis, proliferation, and invasion of endometriosis cells in a particular way. In this regard, defensive substances and cytokines secreted by immune cells impact the endometriosis milieu. Long non-coding RNAs (lncRNAs) mediate gene expression throughout the inflammatory process. According to the current studies, dysfunctional lncRNAs have been linked to several human disorders, including endometriosis. These non-coding RNAs are essential for immunological mechanisms because they regulate interactions between proteins or the capability of RNA and DNA to assemble, which plays a role in differentiation, cell migration, and the synthesis of inflammatory cytokines. Due to the brilliant role of lncRNAs in immune responses and the undeniable role of the immune system in reproduction biology, this study aimed to review the role of deregulated lncRNAs in immune system disorders and its mutual effect on endometriosis formation and development. Further study should identify the significance of lncRNAs linked to the disease via <em>in-vitro</em> and animal model investigations and the importance of uncharacterized lncRNAs found by endometriosis transcriptome studies.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 2","pages":"Article 111248"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0198885925000199","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A chronic illness known as endometriosis impacts women who are of reproductive maturity. It may be a factor in fertility problems, breast or ovarian cancer, asthma, cardiovascular illness, or pelvic pain. Studies have indicated that malfunctioning of the immune system is one of the prerequisites for the occurrence of endometrial diseases. Immune cells such as neutrophils and macrophages seem to be involved in the angiogenesis, proliferation, and invasion of endometriosis cells in a particular way. In this regard, defensive substances and cytokines secreted by immune cells impact the endometriosis milieu. Long non-coding RNAs (lncRNAs) mediate gene expression throughout the inflammatory process. According to the current studies, dysfunctional lncRNAs have been linked to several human disorders, including endometriosis. These non-coding RNAs are essential for immunological mechanisms because they regulate interactions between proteins or the capability of RNA and DNA to assemble, which plays a role in differentiation, cell migration, and the synthesis of inflammatory cytokines. Due to the brilliant role of lncRNAs in immune responses and the undeniable role of the immune system in reproduction biology, this study aimed to review the role of deregulated lncRNAs in immune system disorders and its mutual effect on endometriosis formation and development. Further study should identify the significance of lncRNAs linked to the disease via in-vitro and animal model investigations and the importance of uncharacterized lncRNAs found by endometriosis transcriptome studies.
期刊介绍:
The journal''s scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations.
Research areas include:
Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genes
Studies of the expression, structure and function of the products of immune-related genes
Immunogenetics of susceptibility to infectious and autoimmune disease, and allergy
The role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplant
Histocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivity
Studies of immunologic tolerance and pregnancy
T cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal''s scope
Pharmacogenomics and vaccine development in the context of immune-related genes
Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered.
Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.