Meshfree analysis of brain tumor growth under various treatment plans considering the mechanical stress effect

IF 4.2 2区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY Engineering Analysis with Boundary Elements Pub Date : 2025-02-07 DOI:10.1016/j.enganabound.2025.106151

Amir Khosravifard, Ghazaleh Ansari

{"title":"Meshfree analysis of brain tumor growth under various treatment plans considering the mechanical stress effect","authors":"Amir Khosravifard, Ghazaleh Ansari","doi":"10.1016/j.enganabound.2025.106151","DOIUrl":null,"url":null,"abstract":"<div><div>Brain tumors are among the deadliest types of cancer and the most challenging to treat. Predicting the growth behavior of tumors can help physicians choose the best treatment program. Herein, a numerical technique based on the meshless radial point interpolation methods is presented for simulating the growth of brain tumors under the effects of radiotherapy and chemotherapy. In this work, the stress field induced in the brain due to tumor growth and its effect on tumor diffusion is analyzed. In the meshfree method, to obtain the system of discrete equations, the weak-form of the coupled nonlinear system of governing equations is developed. Part of the simulations is based on clinical data obtained from other research; additionally, data found in the literature is used to validate the results. The effects of various conventional treatment programs, with and without considering the effect of the stress field in brain tissue, are analyzed and compared. Furthermore, the order of radiotherapy and chemotherapy treatments is investigated. It is shown that when the stress effect is considered, the points with maximum stress are where tumor growth is highest. After the cell density reaches its maximum value at these points, growth is transferred to the surrounding areas.</div></div>","PeriodicalId":51039,"journal":{"name":"Engineering Analysis with Boundary Elements","volume":"173 ","pages":"Article 106151"},"PeriodicalIF":4.2000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineering Analysis with Boundary Elements","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955799725000396","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Brain tumors are among the deadliest types of cancer and the most challenging to treat. Predicting the growth behavior of tumors can help physicians choose the best treatment program. Herein, a numerical technique based on the meshless radial point interpolation methods is presented for simulating the growth of brain tumors under the effects of radiotherapy and chemotherapy. In this work, the stress field induced in the brain due to tumor growth and its effect on tumor diffusion is analyzed. In the meshfree method, to obtain the system of discrete equations, the weak-form of the coupled nonlinear system of governing equations is developed. Part of the simulations is based on clinical data obtained from other research; additionally, data found in the literature is used to validate the results. The effects of various conventional treatment programs, with and without considering the effect of the stress field in brain tissue, are analyzed and compared. Furthermore, the order of radiotherapy and chemotherapy treatments is investigated. It is shown that when the stress effect is considered, the points with maximum stress are where tumor growth is highest. After the cell density reaches its maximum value at these points, growth is transferred to the surrounding areas.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Engineering Analysis with Boundary Elements 工程技术-工程：综合

CiteScore

5.50

自引率

18.20%

发文量

368

审稿时长

56 days

期刊介绍： This journal is specifically dedicated to the dissemination of the latest developments of new engineering analysis techniques using boundary elements and other mesh reduction methods. Boundary element (BEM) and mesh reduction methods (MRM) are very active areas of research with the techniques being applied to solve increasingly complex problems. The journal stresses the importance of these applications as well as their computational aspects, reliability and robustness. The main criteria for publication will be the originality of the work being reported, its potential usefulness and applications of the methods to new fields. In addition to regular issues, the journal publishes a series of special issues dealing with specific areas of current research. The journal has, for many years, provided a channel of communication between academics and industrial researchers working in mesh reduction methods Fields Covered: • Boundary Element Methods (BEM) • Mesh Reduction Methods (MRM) • Meshless Methods • Integral Equations • Applications of BEM/MRM in Engineering • Numerical Methods related to BEM/MRM • Computational Techniques • Combination of Different Methods • Advanced Formulations.