Neuroinflammation in kidney disease and dialysis

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES Behavioural Brain Research Pub Date : 2025-02-06 DOI:10.1016/j.bbr.2025.115465

Yumi Watanabe Chagas, Pedro Alves S. Vaz de Castro, Ana Cristina Simões-e-Silva

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Abstract

The complex relationship between chronic kidney disease (CKD) and neuroinflammation shows how important immunological processes are in mediating cognitive dysfunction and psychiatric symptoms in this disease. Proinflammatory cytokines and chemokines, such as IL-1β and IL-6, are capable of crossing the blood-brain barrier, and, consequently, may contribute to neuropsychiatric symptoms including anxiety, depression, and cognitive impairment in CKD patients. The peptides of the renin-angiotensin system (RAS), with their dual functions in inflammation and neuroprotection, also highlight the intricate immunological mechanisms operating within the kidney-brain axis. Understanding these immunological pathways is essential for developing targeted interventions to modulate neuroinflammation and improve cognitive outcomes in individuals with CKD. Further research in renal immunology and neuroinflammation holds promise for advancing our understanding of the intricate connections between kidney health, brain function, and immune responses in the context of CKD. This review summarizes the critical role of immunological factors in the pathophysiology of CKD-related cognitive impairment and psychiatric disorders.

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肾脏疾病和透析中的神经炎症

慢性肾脏疾病（CKD）和神经炎症之间的复杂关系表明，免疫过程在调节这种疾病的认知功能障碍和精神症状中是多么重要。促炎细胞因子和趋化因子，如IL-1β和IL-6，能够穿过血脑屏障，因此，可能导致CKD患者的神经精神症状，包括焦虑、抑郁和认知障碍。肾素-血管紧张素系统（RAS）的多肽具有炎症和神经保护的双重功能，也强调了在肾-脑轴内运作的复杂免疫机制。了解这些免疫途径对于制定有针对性的干预措施来调节神经炎症和改善CKD患者的认知结果至关重要。肾脏免疫学和神经炎症的进一步研究有望促进我们对CKD背景下肾脏健康、脑功能和免疫反应之间复杂联系的理解。本文综述了免疫因子在ckd相关认知障碍和精神障碍病理生理中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.