The role of electrochemistry in solving the mystery of the relationship between molecular structure and anaesthetic potency

Abstract

In this communication, we demonstrate how conventional electrochemical measurements can be exploited in an unconventional way: the goal is the pursuit of a relationship between molecular structure of anaesthetics and the relevant anaesthetic potency. To this end, cyclic voltammetry and linear scan voltammetry curves are recorded in the presence in solution of molecules, like $CH{Cl}_3$, with a significant spin-orbit coupling (SOC), aiming to single out the role of spin in the oxygen reduction reaction (ORR). Indeed, compounds featuring high SOC values reduce the efficiency of the ORR, yielding a substantial decrease in the ORR current. ORR spin-dependence is also investigated using spin-polarized currents, employing ferromagnetic nickel and chiral gold surfaces, exploiting the chiral-induced spin selectivity effect. Remarkably, halothane, which is a well-known anaesthetic has a pronounced effect on ORR current reduction.